Oxygen-Tight Envelope for Plastic Syringe

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Solution Overview

Problem

The storage of oxygen-sensitive active pharmaceutical ingredients, such as propofol, in conventional glass containers is expensive and prone to contamination during transfer, and glass receptacles are not resistant to breakage in pump systems.

Innovation Solution

A delivery syringe with a prefilled plastic receptacle filled with oxygen-sensitive active pharmaceutical ingredients, enveloped in an oxygen-tight envelope, which includes a siliconized inner surface and is made from cyclic olefin copolymer to prevent oxygen penetration and protect the ingredients, along with an optional oxygen absorber to further reduce oxygen exposure.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If glass containers are used to store oxygen-sensitive active pharmaceutical ingredients, then oxygen-tight storage is achieved, but the cost increases and breakage resistance decreases

Engineering Contradiction:

Improveoxygen-tight storageVSAvoidbreakage resistance

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The patent uses a composite packaging system consisting of a plastic receptacle (inner layer) combined with an oxygen-tight envelope (outer layer). The plastic receptacle provides breakage resistance while the oxygen-tight envelope provides oxygen barrier protection, creating a composite solution that resolves the contradiction between strength and oxygen-tight storage.

Inventive Principle:

Principle #40Composite materials

2Reliability

If glass receptacles are used for storing oxygen-sensitive active pharmaceutical ingredients, then oxygen protection is provided, but the device complexity and handling difficulty increase

Engineering Contradiction:

Improveoxygen protectionVSAvoidhandling ease

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent employs a disposable plastic receptacle system that is designed for single-use after transfer of the active pharmaceutical ingredient. This eliminates the need for complex cleaning and sterilization procedures associated with glass receptacles, improving ease of operation while maintaining oxygen protection through the combined plastic receptacle and oxygen-tight envelope design.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Ease of operation

If active pharmaceutical ingredients are transferred from storage containers to delivery syringes, then administration is enabled, but contamination risk increases

Engineering Contradiction:

Improveadministration capabilityVSAvoidcontamination risk

Core Design Contradiction:

Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The patent designs the plastic receptacle with a nozzle and closure system that allows the active pharmaceutical ingredient to be pre-filled and sealed. The closure can be detached to enable transfer to a delivery syringe, while the pre-filled design minimizes exposure to contamination risks during the filling process.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The nozzle and closure system act as an intermediary mechanism that controls the transfer of the active pharmaceutical ingredient from the storage receptacle to the delivery syringe. This controlled interface reduces contamination risk by providing a defined transfer path while enabling administration capability.

Inventive Principle:

Principle #24Intermediary (Mediator)

4Strength

If plastic receptacles are used instead of glass, then breakage resistance improves, but oxygen penetration increases

Engineering Contradiction:

Improvebreakage resistanceVSAvoidoxygen barrier property

Core Design Contradiction:

StrengthVSReliability

Solution Approach 1:

The patent employs a composite packaging system consisting of a plastic receptacle (inner layer) combined with an oxygen-tight envelope (outer layer). The plastic receptacle provides breakage resistance while the oxygen-tight envelope provides oxygen barrier protection, creating a composite solution that resolves the contradiction between strength and oxygen-tight storage.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This solution allows for long-term storage and administration of oxygen-sensitive active pharmaceutical ingredients while preventing contamination and breakage, reducing costs and improving safety by using a durable and efficient plastic receptacle system.

Implementation Method 1

an oxygen-tight envelope which envelopes the delivery syringe in an oxygen-tight manner

Methodology Applied

Scientific EffectOxygen barrier: Permeation

Implementation Method 2

an inner surface of the plastic receptacle is siliconized at least in sections. This siliconization can in particular increase the sliding capacity of a plunger in the plastic receptacle

Methodology Applied

Scientific EffectSiliconization: Coatings

Data Source

PatentUS11452811B2Application arrangement with a medicinal substance fluid

Publication Date: 2022.09.27 FRESENIUS KABI AUSTRIA GMBH

AI summary

A pharmaceutical product includes a delivery syringe comprising a plastic receptacle and an oxygen-tight envelope which envelopes the delivery syringe in an oxygen-tight manner, wherein the plastic receptacle is filled with an oxygen-sensitive active pharmaceutical ingredient fluid and an inner surface of the plastic receptacle is siliconized at least in sections.