Oxygenation Device for Hemoglobin Carrier Delivery
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Solution Overview
Problem
Current systems for delivering oxygen carriers, such as liposome encapsulated hemoglobin, face inefficiencies in delivering oxygen to ischemic tissues due to premature oxygen detachment before reaching the target tissue.
Innovation Solution
A system that oxygenates a deoxygenated hemoglobin-based oxygen carrier just before administration using an oxygenation part located between the housing and the microcatheter, ensuring efficient oxygen delivery to ischemic tissues while preventing conversion to methemoglobin.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the oxygen carrier is stored in an oxygenated state to maintain oxygen availability, then the oxygen carrying capacity is maintained, but the hemoglobin converts to methemoglobin form which cannot bind oxygen
Solution Approach 1:
The system performs preliminary oxygenation of the oxygen carrier in a controlled manner before delivery, using an oxygenation part that allows selective oxygenation. The housing is designed to maintain the oxygen carrier in a deoxygenated state during storage, and oxygenation is performed just before administration through the long element, preventing methemoglobin conversion while ensuring oxygen availability at the target site
Solution Approach 2:
The housing creates a protected environment that isolates the oxygen carrier from atmospheric oxygen during storage and transport. This inert environment prevents spontaneous oxidation of hemoglobin to methemoglobin, maintaining the oxygen carrier in a stable, deoxygenated state until deliberate oxygenation occurs at the administration site
2Reliability
If the oxygen carrier is administered systemically to reach ischemic tissue, then the oxygen can be delivered to the target tissue, but oxygen detaches from the carrier before reaching the ischemic tissue
Solution Approach 1:
The system extracts the oxygenation function from the storage and delivery system by providing a separate oxygenation part that activates just before administration. The long element is designed to deliver the oxygen carrier directly to the ischemic tissue through a catheter, bypassing systemic circulation and preventing premature oxygen detachment that occurs in systemic administration
Solution Approach 2:
The long element acts as an intermediary delivery vehicle that transports the oxygen carrier directly from the housing to the ischemic tissue. This direct delivery pathway eliminates the intermediate step of systemic circulation, preventing premature oxygen detachment and ensuring the oxygen carrier reaches the target tissue intact
3Reliability
If the housing allows oxygen permeation to maintain oxygen carrier readiness, then oxygen availability is improved, but the oxygen carrier oxidizes to methemoglobin during storage
Solution Approach 1:
The housing is designed to maintain an oxygen-excluding environment during storage, preventing oxidation of the oxygen carrier. The housing material and structure are configured to block oxygen permeation during the storage phase, keeping the hemoglobin in a stable, deoxygenated state for extended periods
Solution Approach 2:
The housing transitions from a static, oxygen-blocking state during storage to a dynamic, oxygen-permeable state during administration. The housing includes an oxygenation part that can be activated to allow controlled oxygen permeation just before and during delivery, enabling the oxygen carrier to become oxygenated only when needed
Data Source
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AI summary
To provide a system for delivering an oxygen carrier, whereby a deoxygenated oxygen carrier can be oxygenated and efficiently delivered to an ischemic tissue, an oxygenation device for an oxygen carrier, and a housing for an oxygen carrier. A system (10) for delivering an oxygen carrier, the system including: a housing (2) in which a hemoglobin-based oxygen carrier is housed in a deoxygenated state; an oxygenation part for oxygenating the deoxygenated oxygen carrier; and a long element (5) which can be inserted into a living organism and can release the oxygenated oxygen carrier through a lumen (52) that is formed inside thereof.