Packaged Formulation Stabilizing Components for Cannabinoid Purity
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Solution Overview
Problem
Cannabinoids such as cannabidiol (CBD) and tetrahydrocannabinol (THC) in aerosol formulations are prone to degradation and oxidation when exposed to air, light, or variations in temperature and pH, leading to unintended conversion into derivatives like cannabidiol hydroxyquinone (CBDHQ) and Δ9-tetrahydrocannabinol (Δ9-THC, which can result in reduced purity and regulatory issues.
Innovation Solution
Incorporating stabilizing components like antioxidants, radical scavengers, and pH modulators into the formulation, combined with controlled exposure to gaseous oxygen, to mitigate the oxidation and degradation of cannabinoids, ensuring high purity and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If cannabinoids are exposed to air, light, or temperature variations, then aerosol generation is enabled, but oxidation and degradation occur leading to reduced purity
Solution Approach 1:
The patent employs an inert atmosphere (nitrogen or carbon dioxide) to displace oxygen and prevent oxidation of cannabinoids during storage and aerosol generation. This creates a protective environment that maintains cannabinoid purity while still allowing the aerosol delivery function to operate.
Solution Approach 2:
The patent introduces stabilizing components as intermediaries between cannabinoids and degrading factors. These stabilizers act as sacrificial agents that protect cannabinoids from oxidation and degradation, maintaining purity while enabling continuous aerosol generation.
2Reliability
If stabilizing components are added to the formulation, then cannabinoid stability is improved, but formulation complexity increases
Solution Approach 1:
The patent optimizes the concentration levels of stabilizing components within specific ranges (0.01-10% w/w) to achieve effective protection without excessive complexity. By carefully controlling these parameters, the formulation maintains stability while avoiding unnecessary complexity.
Solution Approach 2:
The stabilizing components serve multiple functions simultaneously: they act as antioxidants, radical scavengers, and pH modulators. This multi-functionality reduces the need for multiple separate additives, thereby limiting the increase in formulation complexity while achieving comprehensive stability protection.
3Reliability
If antioxidant stabilizing components are used, then oxidation is prevented, but manufacturing cost increases
Solution Approach 1:
The patent specifies concentration ranges (0.01-10% w/w) that balance effective oxidation prevention with cost efficiency. By optimizing within these ranges, the formulation achieves protection without using excessive amounts of expensive stabilizing components.
Solution Approach 2:
The patent employs food-grade or pharmaceutical-grade stabilizing components that are relatively inexpensive and can be easily replaced. These stabilizers are designed to be consumable, allowing for cost-effective manufacturing while maintaining adequate protection during the product shelf life.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of stabilizing components effectively maintains the purity and stability of cannabinoids, preventing unwanted conversions and ensuring compliance with regulatory standards, even under varying environmental conditions.
Implementation Method 1
Cannabinoids such as cannabidiol (CBD) and tetrahydrocannabinol (THC) in aerosol formulations are prone to degradation and oxidation when exposed to air
Implementation Method 2
Incorporating stabilizing components like antioxidants, radical scavengers, and pH modulators into the formulation, combined with controlled exposure to gaseous oxygen, to mitigate the oxidation and degradation of cannabinoids
Implementation Method 3
said packaging is impermeable to air
Data Source
AI summary
A packaged formulation, a method of making said packaged formulation, as well as containers and systems including and using said packaged formulation. In particular, the packaged formulation includes one or more cannabinoids and one or more stabilizing components, wherein said packaging is impermeable to air.