Pain Suppression Apparatus Using Dynamic Waveform Modulation

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Solution Overview

Problem

Current pain therapy technologies, such as TENS and implanted electric stimulators, are ineffective for high-grade chronic pain and neuropathic pain resistant to conventional analgesics, with unsatisfactory reproducibility and patient compliance issues due to limited dynamic range and recruitment of nerve fibers.

Innovation Solution

Development of an apparatus generating synthetic 'non-pain' information strings with complex waveform geometries and dynamic assembly structures, engaging a wider range of nerve fibers and using novel control algorithms to create more effective analgesic signals.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional TENS or implanted electric stimulators are used, then the apparatus is simple and easy to operate, but the analgesic effect is unsatisfactory for high-grade chronic pain and neuropathic pain

Engineering Contradiction:
Improveanalgesic effectivenessVSAvoidsignal generation complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent implements dynamic frequency and amplitude modulation of the electrical stimulus, allowing the signal parameters to vary over time according to pre-programmed sequences. This dynamic adjustment enables the system to adapt to different pain states and nerve fiber recruitment requirements, significantly improving analgesic effectiveness for resistant pain types while maintaining reasonable device complexity through automated control algorithms.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The system employs systematic changes in multiple signal parameters including frequency (5-100 Hz), amplitude, and duty cycle, with automatic scanning capabilities that adjust these parameters in predetermined sequences. This multi-parameter modulation approach allows the apparatus to target different nerve fiber types and pain pathways, resolving the contradiction between signal complexity and therapeutic effectiveness.

Inventive Principle:
Principle #35Parameter changes

2Extent of automation

If automatic frequency and amplitude scanning is implemented, then the operation is automated, but the reproducibility and patient compliance remain unsatisfactory

Engineering Contradiction:
Improvesignal control automationVSAvoidclinical reproducibility
Core Design Contradiction:
Extent of automationVSReliability

Solution Approach 1:

The patent pre-programs specific frequency and amplitude sequences that have been optimized based on clinical research and Gate Control theory principles. These predetermined scanning patterns ensure consistent and reproducible nerve fiber recruitment across different patients and treatment sessions, while maintaining full automation of the signal delivery process. The pre-programmed sequences eliminate operator variability and ensure clinically validated parameter ranges are always used.

Inventive Principle:
Principle #10Preliminary action

3Reliability

If high-frequency stimulation is used to block pain transmission, then the analgesic effect is stronger, but the patient compliance decreases due to tolerability issues

Engineering Contradiction:
Improvepain suppression efficacyVSAvoidpatient compliance
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The system uses periodic modulation of the electrical stimulus with variable duty cycles, alternating between active stimulation phases and rest periods. This periodic action allows high-frequency bursts sufficient for pain blocking to be delivered intermittently, reducing cumulative sensory overload and patient discomfort while maintaining effective analgesia during active phases. The automated programming ensures optimal rest-stimulation ratios are maintained throughout treatment.

Inventive Principle:
Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution achieves high reproducibility and patient compliance by generating effective 'non-pain' information strings that provide immediate and long-term analgesia, overcoming limitations of existing technologies in treating resistant pain types.

Implementation Method 1

Pain therapy by electrostimulation is practiced with apparatuses normally producing wave trains ranging from 5 to 100 Hz

Methodology Applied
Scientific EffectElectrical stimulation: Conduction (electrical)

Implementation Method 2

More reliable is the explanation of operation according to Gate Control theory. Accordingly, these electric stimulations are deemed to have an inhibiting function on painful stimulus transmission, by blocking electric-type nerve conduction.

Methodology Applied
Scientific EffectGate control theory mechanism:

Data Source

PatentEP2195088B1Apparatus and signal for quick pain suppression, and method of generating such a singal
Publication Date: 2013.03.27 MARINEO GIUSEPPE
  • EP2195088B1 patent drawingFigure 1
  • EP2195088B1 patent drawingFigure 2A~2B
  • EP2195088B1 patent drawingFigure 2C~2D

AI summary

The present invention refers to an apparatus and a method for quick acute and chronic pain suppression, particularly useful and effective towards high-grade pains and/or pains resistant to other analgesic drugs such as opiates. According to the present invention there are generated synthetic "non-pain" information strings of great clinical effectiveness, allowing high reproducibility of the clinical result. Synthesis occurs by combining novel geometries of complex waveforms in a sequence, perceived as "self and "non-pain" by the CNS.