Palm Fruit Juice Composition for Delaying Aging via Gene Regulation

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Solution Overview

Problem

Current approaches to delaying aging and increasing longevity are limited by the use of synthetic antioxidants with side effects and lack of natural, effective compositions that can address the complex mechanisms of aging through multiple pathways.

Innovation Solution

A composition comprising Palm Fruit Juice (PFJ) extracts or its fractions, combined with other components, which includes bioactive water-soluble compounds like phenolics, shikimic acid, and soluble fibre, is used to regulate hormetic stress response genes and downregulate the TOR-related regulatory network, promoting longevity and delaying aging.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If synthetic antioxidants are used to delay aging, then antioxidant effect is improved, but side effects increase

Engineering Contradiction:

Improveantioxidant effectVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters by using natural phenolic compounds (caffeoyl shikimic acid isomers) instead of synthetic antioxidants, maintaining antioxidant efficacy while eliminating harmful side effects through natural origin and specific molecular structure characteristics

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs a composite approach by combining multiple phenolic compounds (p-hydroxybenzoic acid, caffeoyl shikimic acid isomers) and other bioactive components from palm fruit juice to create a synergistic formulation that enhances antioxidant effect while reducing individual component toxicity

Inventive Principle:

Principle #40Composite materials

2Object-affected harmful factors

If natural antioxidants are used to delay aging, then safety is improved, but effectiveness is insufficient

Engineering Contradiction:

ImprovesafetyVSAvoideffectiveness

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent optimizes the concentration and ratio parameters of phenolic compounds in the composition to achieve maximum effectiveness, with specific focus on caffeoyl shikimic acid isomers that demonstrate potent antioxidant activity while maintaining natural safety profile

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a synergistic composite formulation combining multiple natural phenolic compounds and bioactive components from palm fruit juice, where the combination produces enhanced antioxidant effectiveness greater than individual components alone while maintaining safety

Inventive Principle:

Principle #40Composite materials

3Device complexity

If single-component antioxidants are used, then simplicity is improved, but ability to address complex aging mechanisms is insufficient

Engineering Contradiction:

Improvecomposition simplicityVSAvoidability to address complex aging mechanisms

Core Design Contradiction:

Device complexityVSAdaptability or versatility

Solution Approach 1:

The patent designs a multi-functional composition where phenolic compounds from palm fruit juice simultaneously address multiple aging mechanisms including oxidative stress, inflammation, and cellular senescence, making the single composition capable of tackling complex aging processes through diverse biological pathways

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The PFJ-based composition effectively delays aging and increases longevity by modulating growth dynamics, enhancing oxidative stress resistance, and regulating key genes and pathways associated with aging, as demonstrated in fruit fly models, with potential implications for human health.

Implementation Method 1

Methodology Applied

Scientific EffectGene expression regulation:

Implementation Method 2

regulating hormetic stress response genes linked to ageing and longevity, to delay ageing in a human subject... down regulating tor-related regulatory network

Methodology Applied

Scientific EffectSignal transduction pathway modulation:

Implementation Method 3

enhancing oxidative stress resistance... regulating key genes and pathways associated with aging

Methodology Applied

Scientific EffectAntioxidant enzyme activity:

Data Source

PatentUS11446350B2Composition for delaying aging process and increasing longevity in a subject and methods thereof

Publication Date: 2022.09.20 MALASIAN PALM OIL BOARD

AI summary

The present invention relates to processes and composition meant for delaying ageing process in a subject comprising of palm fruit juice whole or its fractions, alone or in combination with other components in the form of a composition. Palm Fruit Juice alone or in combination with other additives can be administered preferably orally in pharmaceutically acceptable dosage forms.