Palmitoyl-Lys-Thr Dipeptide for Keratinous Tissue Aging
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Solution Overview
Problem
Current personal care products, particularly those containing dipeptides like Lys-Ser, often fail to provide adequate benefits for maintaining the health and cosmetic appearance of skin, hair, and nails due to inadequate properties, leading to issues such as thinning and degradation caused by aging and environmental factors.
Innovation Solution
The use of the dipeptide palmitoyl-lys-thr, combined with a dermatologically or orally acceptable carrier, in personal care compositions to regulate the condition of mammalian keratinous tissue, either through topical application or oral ingestion, offering superior properties compared to traditional dipeptides.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional dipeptides like Lys-Ser are used in personal care compositions, then the compositions can be formulated with simple structures, but they provide inadequate benefits for maintaining skin, hair, and nail health due to insufficient dermopharmaceutical and cosmetic activity
Solution Approach 1:
The patent changes the chemical parameters of the dipeptide by substituting the C-terminal amino acid from serine to threonine and adding a palmitoyl group at the N-terminal, transforming Lys-Ser into palmitoyl-Lys-Thr. This parameter change enhances dermopharmaceutical activity while maintaining formulation feasibility
Solution Approach 2:
The invention creates a composite dipeptide structure by combining palmitoyl group with Lys-Thr dipeptide. This composite structure provides superior dermopharmaceutical and cosmetic properties compared to simple dipeptides like Lys-Ser, resolving the contradiction between activity and complexity
2Reliability
If the skin, hair, and nails are exposed to extrinsic and intrinsic factors over time, then chronological aging and environmental damage occur naturally, but this results in visible signs of aging and degradation such as thinning and loss of mechanical resistance
Solution Approach 1:
The patent applies palmitoyl-Lys-Thr dipeptide as a preventive treatment that counteracts aging factors before significant degradation occurs. The dipeptide works prophylactically to maintain mechanical resistance and prevent thinning of the dermal-epidermal junction, addressing harmful factors in advance
Solution Approach 2:
The invention converts the natural aging process from a harmful degradation mechanism into a manageable condition through topical application. The dipeptide targets specific aging effects like flattening of the dermal-epidermal junction and transforms the outcome from degradation to maintenance or improvement of mechanical resistance
Data Source
AI summary
Personal care compositions comprising a dipeptide and methods of using such compositions to treat the condition of keratinous tissue. The C terminal amino acid of said dipeptide is threonine. The personal care composition can be applied topically, ingested orally, injected, or used as part of a combined treatment regimen.