Palmitoylethanolamide and Phyllanthus niruri Composition for Urinary Stone Management
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Solution Overview
Problem
Current treatments for urinary stones are inadequate in preventing and treating the symptomatology, particularly in addressing pain and inflammation associated with stone obstruction in the urinary tract.
Innovation Solution
A composition combining palmitoylethanolamide and Phyllanthus niruri extract, which provides analgesic and anti-inflammatory effects by enhancing endocannabinoid activity and inhibiting leukocyte migration and pain, respectively, facilitating the expulsion of stones.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for urinary stones, then basic symptom management is provided, but pain and inflammation associated with stone obstruction are not adequately addressed
Solution Approach 1:
The patent combines two distinct therapeutic agents into a single composition: palmitoylethanolamide (an analgesic anti-inflammatory agent) and Phyllanthus niruri extract (a lithontriptic agent that promotes stone fragmentation and expulsion). This synergistic combination addresses multiple aspects of urinary stone pathology simultaneously - pain management, inflammation reduction, and stone expulsion facilitation - thereby resolving the contradiction between basic symptom management and adequate pain/inflammation control
Solution Approach 2:
The invention creates a composite pharmaceutical composition integrating compounds with different mechanisms of action. Palmitoylethanolamide provides analgesic and anti-inflammatory effects through endocannabinoid system modulation, while Phyllanthus niruri extract contributes lithontriptic properties through its ability to inhibit crystal formation and promote stone fragmentation. This composite approach enables simultaneous targeting of multiple pathological processes that single-agent therapies cannot address effectively
2Object-affected harmful factors
If stone obstruction is present in the urinary tract, then urinary flow is blocked causing severe pain, but current treatments do not sufficiently reduce inflammation and pain simultaneously
Solution Approach 1:
The patent merges analgesic, anti-inflammatory, and lithontriptic functions into a single integrated composition. By combining palmitoylethanolamide (which activates PPAR-alpha receptors to reduce pain and inflammation) with Phyllanthus niruri extract (which promotes stone fragmentation), the treatment addresses both symptom management and underlying pathology without requiring multiple separate interventions, thus managing complexity while providing comprehensive relief
3Reliability
If urinary stones are not adequately treated, then chronic kidney disease can develop, but current treatments do not sufficiently promote stone expulsion
Solution Approach 1:
The patent employs preliminary action by using Phyllanthus niruri extract to prevent stone formation and promote early fragmentation before stones become large and difficult to expel. The extract inhibits crystal aggregation and promotes disintegration of existing stones, creating favorable conditions for spontaneous passage. This preliminary lithontriptic action, combined with palmitoylethanolamide's anti-inflammatory effects that reduce ureteral edema, significantly enhances stone expulsion rates and prevents progression to chronic kidney disease
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination effectively reduces pain and inflammation, promoting the resolution of kidney damage and normalizing oxalate and calcium levels, thereby aiding in the prevention and treatment of urinary stones.
Implementation Method 1
provides analgesic and anti-inflammatory effects by enhancing endocannabinoid activity
Implementation Method 2
inhibiting leukocyte migration and pain
Data Source
AI summary
The present invention relates to a composition comprising palmitoylethanolamide and an extract of Phyllanthus niruri. The use of the composition as a food supplement, medicament, medical device or food for special medical purposes, in particular in preventing and/or treating the symptomatology of urinary stones characterized by pain and inflammation is also provided.