Panax Plant Extract with Optimized Ginsenoside Ratios

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Solution Overview

Problem

Current ginseng extracts do not effectively maximize the physiological activity of key ginsenosides like Rg3, Rk1, Rg5, Rg2, Rh1, and Rh2, which are crucial for therapeutic benefits, due to suboptimal mass ratios and extraction methods.

Innovation Solution

A Panax plant extract is developed with controlled mass ratios of Rk1 and Rg5 to Rg3, and Rg2, optimized through a specific extraction process involving deglycosylation and dehydration of Panaxadiol Ginsenosides Rb1 and Rb2, resulting in a composition that enhances the physiological activity of the extract.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional extraction methods are used for ginseng, then the extraction process is simple and cost-effective, but the content of active ginsenosides (Rg3, Rk1, Rg5, Rg2, Rh1, Rh2) is insufficient and physiological activity is not maximized

Engineering Contradiction:

Improvecontent of active ginsenosidesVSAvoidextraction process complexity

Core Design Contradiction:

Quantity of substanceVSDevice complexity

Solution Approach 1:

The extraction process is divided into multiple sequential steps: initial extraction, filtration, concentration, and drying. Each step isolates and optimizes for specific components, progressively increasing the concentration of active ginsenosides while managing process complexity through systematic breakdown of the extraction workflow

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent performs preliminary extraction and filtration steps before concentration and drying. By preparing the extract in advance through these preliminary actions, the process ensures maximum recovery of active ginsenosides before final processing, thereby increasing quantity of active substances while maintaining organized process flow

Inventive Principle:

Principle #10Preliminary action

2Reliability

If the mass ratio of Rk1 and Rg5 to Rg3 is not optimized, then the extraction process is simpler, but the physiological activity and therapeutic efficacy are reduced

Engineering Contradiction:

Improvephysiological activityVSAvoidmass ratio control

Core Design Contradiction:

ReliabilityVSManufacturing precision

Solution Approach 1:

The patent systematically adjusts and optimizes the mass ratio parameters of Rk1, Rg5, and Rg3 through controlled extraction conditions. By changing extraction parameters such as solvent composition, temperature, and time, the process achieves the optimal mass ratio (Rk1+Rg5)/Rg3 within 0.5-1.5, thereby maximizing physiological activity while establishing clear manufacturing specifications

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent establishes quality control mechanisms to monitor and adjust the mass ratios of ginsenosides during extraction. Through feedback on the composition of the extract, the process can be adjusted to maintain the optimal ratio range, ensuring consistent physiological activity and therapeutic efficacy across production batches

Inventive Principle:

Principle #23Feedback

3Reliability

If extraction focuses on all ginsenosides equally, then the extraction process is straightforward, but the therapeutic efficacy for specific conditions (Alzheimer's, blood glucose regulation, thrombosis) is not optimized

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidextraction process simplicity

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent applies local quality by optimizing the extraction process for specific therapeutic targets. By adjusting extraction parameters to enrich specific ginsenosides (Rg3, Rk1, Rg5, Rg2, Rh1, Rh2) in controlled ratios, the extract achieves enhanced therapeutic efficacy for specific conditions such as Alzheimer's, blood glucose regulation, and thrombosis, while maintaining a manageable extraction process through targeted optimization rather than comprehensive extraction

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The optimized Panax plant extract significantly improves the therapeutic efficacy by increasing the content of active ginsenosides, achieving improved physiological activity and treatment outcomes for conditions such as Alzheimer's, blood glucose regulation, blood fat reduction, dysmenorrhea, and thrombosis, while maintaining safety and effectiveness.

Implementation Method 1

When -Glc-Glc or -Glc-Ara (pyr) is deglycosylated at position 20, the original Panaxadiol Ginsenoside Rb1 and Rb2 can produce 20(S)-Rg3 and 20(R)-Rg3

Methodology Applied

Scientific EffectDeglycosylation: Hydrolysis

Implementation Method 2

if dehydration occurs at the position 20 of 20(S)-Rg3 and 20(R)-Rg3, Rg5 and Rk1 can be produced

Methodology Applied

Scientific EffectDehydration:

Data Source

PatentEP3572088B1A panax plant extract and pharmaceutical composition and use thereof

Publication Date: 2023.08.16 SHANGHAI HONGYITANG BIOPHARM CO LTD

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AI summary

Disclosed a Panax plant extract and a pharmaceutical composition and the use thereof. The mass ratio of Rk1 and Rg5 in the Panax plant extract is 1:1.0-1.5, and the content of Rg3, Rg5 and Rk1 in the extract is relatively high. The extract can be used to prepare a drug for treating chronic heart failure, coronary stable angina, arrhythmia, diabetes and complications thereof, Meniere's disease, hyperlipemia, fatty liver, Alzheimer's disease, dymenorrhea, metabolic syndrome, gout, tumours or vascular leak syndrome.