Aqueous Composition for Pancreatic Fluid Leakage Detection
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Solution Overview
Problem
Current methods for detecting pancreatic fluid leakage during pancreatic surgery are imprecise and unsafe, as they rely on indirect measurements or require complex and potentially toxic fluorescent probes, making it difficult to visualize and localize the leakage in real-time, which can lead to postoperative complications.
Innovation Solution
A body fluid leakage detection aqueous composition comprising cross-linked α-glucan or dextran microspheres as a gelling agent, combined with a pH-indicator like bromothymol blue, which increases viscosity and provides a buffered solution, allowing for precise visualization of pancreatic fluid leakage by color change during surgery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If fluorescent probes are used to detect pancreatic fluid leakage, then detection sensitivity is improved, but device complexity and safety risks increase due to UV-light illumination requirements and potential toxicity
Solution Approach 1:
The patent extracts and eliminates the complex UV-illumination system and light-blocking glasses from the detection method, replacing fluorescent probe detection with a simple color-changing pH indicator that works under normal surgical lighting conditions, thereby resolving the contradiction between detection sensitivity and device complexity
Solution Approach 2:
The patent uses a simple, inexpensive pH indicator solution that can be easily applied and discarded, replacing expensive and complex fluorescent probes, thus reducing device complexity while maintaining detection effectiveness
2Measurement precision
If fluorescent probes are used to detect pancreatic fluid leakage, then detection sensitivity is improved, but safety deteriorates due to potential toxicity and UV-radiation damage
Solution Approach 1:
The patent converts the harmful UV-radiation requirement into a beneficial feature by using a pH indicator that responds to the naturally alkaline pH of pancreatic fluid, eliminating the need for UV illumination and associated safety risks while maintaining detection sensitivity
Solution Approach 2:
The patent replaces potentially toxic fluorescent probes with a safe, biocompatible pH indicator solution that poses no radiation or toxicity risks, thus resolving the safety contradiction
3Object-affected harmful factors
If indirect measurement of amylase concentration is used to detect pancreatic fluid leakage, then safety is improved by avoiding toxic substances, but measurement precision deteriorates due to inability to directly visualize and localize leakage
Solution Approach 1:
The patent applies a pH indicator that undergoes visible color change when exposed to pancreatic fluid, enabling direct visualization and precise localization of leakage sites while maintaining safety by using a non-toxic indicator, thus resolving the contradiction between safety and measurement precision
4Ease of operation
If existing pancreatic juice developers are used, then ease of operation is improved by providing simple dosage forms, but measurement precision deteriorates due to difficulty in identifying exact leakage point
Solution Approach 1:
The patent uses a pH indicator that produces a distinct color change at the exact location where pancreatic fluid contacts the indicator, enabling precise localization of leakage points while maintaining ease of operation through simple application methods
Solution Approach 2:
The patent applies the indicator in a manner that creates localized color changes only at the leakage site, allowing precise identification of the exact leakage point while maintaining ease of operation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition enables rapid, precise localization of pancreatic fluid leakage, reducing the risk of postoperative complications by providing a safe, degradable, and reusable means to detect and treat leaks during both open and laparoscopic surgeries.
Implementation Method 1
The composition further comprises a pH-indicator. The pH of the composition is at least 0.1 pH units lower, or higher, than a pKa of the pH-indicator
Implementation Method 2
a body fluid leakage detection aqueous composition comprising cross-linked α-glucan or dextran microspheres as a gelling agent, which increases viscosity
Data Source
AI summary
A body fluid leakage detection aqueous composition, for use e.g. in intraoperative pancreatic fluid leakage detection. The composition comprises a gelling agent, increasing the viscosity of the composition, and buffering species, the composition thereby being buffered. The gelling agent is cross-linked α-glucan microspheres. Further, the composition comprises a pH-indicator. The pH of the composition is at least 0.1 pH units lower, or higher, than a pKa of the pH-indicator.