Panduratin A Pinostrobin Composition Inhibiting Coronavirus Replication
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Solution Overview
Problem
Current treatments for COVID-19, particularly caused by SARS-CoV-2, lack effective and safe therapeutic options, with existing drugs showing varying efficacy and severe side effects, highlighting the need for alternative antiviral agents from natural sources.
Innovation Solution
A pharmaceutical composition comprising Panduratin A and Pinostrobin, in a molar ratio of 1:4 to 1:10, derived from Boesenbergia sp., which inhibits coronavirus replication, including SARS-CoV-2, by interacting with viral protease and exerting antioxidant effects, potentially used as a medicament, prophylactic, or supplement with low toxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing antiviral drugs (chloroquine, hydroxychloroquine, favipiravir, lopinavir/ritonavir, remdesivir) are used for COVID-19 treatment, then viral replication is inhibited to some extent, but severe side effects and controversial efficacy occur
Solution Approach 1:
The patent employs natural product-based medicines from Thai traditional herbs as alternative antiviral agents. These natural compounds are presented as safer, more affordable alternatives to expensive FDA-approved drugs with severe side effects, aligning with the principle of using simpler, more benign substances to achieve therapeutic effects without the harmful consequences of conventional pharmaceuticals
Solution Approach 2:
The patent identifies and utilizes specific phytochemicals (flavonoids, coumarins, alkaloids, terpenes) from natural products, changing the chemical parameters of the treatment approach. By extracting and purifying active compounds from plant sources, the invention creates new therapeutic agents with different pharmacological profiles that avoid the severe side effects of existing drugs while maintaining antiviral efficacy
2Object-affected harmful factors
If natural product-based medicines from Thai traditional herbs are used, then safety and affordability improve, but lack of clinical data and standardization problems occur
Solution Approach 1:
The patent extracts and isolates specific active phytochemicals from complex plant materials. By taking out individual compounds (flavonoids, coumarins, alkaloids, terpenes) from the complex mixture of natural products, the invention enables precise identification, quantification, and standardization of active ingredients, thereby providing the clinical data and measurement precision needed for regulated medical use while maintaining the safety advantages of natural sources
Solution Approach 2:
The patent transforms traditional herbal preparations into standardized pharmaceutical formulations with defined concentrations and purities. By changing the physical and chemical parameters of the natural products through extraction, purification, and formulation processes, the invention creates standardized medications that can be reliably measured, dosed, and monitored clinically, addressing the data availability issue while preserving natural product safety
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively inhibits viral replication, offering a synergistic therapeutic effect when combined with other antiviral agents, potentially providing a safer and more potent alternative to existing treatments by reducing viral load and boosting immune response.
Implementation Method 1
The disclosed composition is capable of or can be used for prohibiting progress of viral replication in a subject infected with coronavirus such as SARS, MERS, and/or COVID-19
Implementation Method 2
Panduratin A and Pinostrobin, or a plant extract containing the mentioned composition capable of prohibit replication of coronavirus
Data Source
AI summary
The present invention relates to a pharmaceutical composition capable of inhibiting replication of coronavirus in a subject upon administrating the composition in an effective amount to the subject, the composition comprising an extract acquired from a plant part of Boesenbergia sp. having Panduratin A and Pinostrobin in a molar ratio of 1:4 to 1:10. The composition may further comprise or incorporated with or being used along with an antiviral agent to achieve a synergistic effect against coronavirus.