Pantethine Trisulfide Composition for Redox-Active Physiological Effects

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Solution Overview

Problem

There is a need for novel trisulfide compounds that exhibit physiologically active functions, particularly in terms of oxidation-reduction ability, and can be converted into pantethine and pantetheine to provide effects such as vasodilation, anti-inflammatory, neuroprotective, and cardioprotective benefits.

Innovation Solution

The development of pantethine trisulfide, represented by Formula (1), which can be converted into pantethine and pantetheine, and has the potential to react with hydrogen sulfide or cysteine residues of proteins, exhibiting various physiological effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional disulfide compounds are used, then basic antioxidant function is provided, but oxidation-reduction ability and physiological activity are limited

Engineering Contradiction:

Improveoxidation-reduction abilityVSAvoidphysiological activity

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the chemical parameter from disulfide (—S—S—) to trisulfide (—S—S—S—) bonding structure. This parameter change enables the compound to exhibit both oxidation and reduction reactions, providing reversible oxidation-reduction ability that enhances physiological activity while maintaining stability

Inventive Principle:

Principle #35Parameter changes

2Reliability

If trisulfide compound is designed for high oxidation-reduction ability, then physiological activity is improved, but stability and convertability to active forms may be compromised

Engineering Contradiction:

Improvephysiological activityVSAvoidcompound stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The trisulfide bonding structure parameter enables the compound to maintain stability while possessing oxidation-reduction ability. The unique —S—S—S— structure allows reversible oxidation and reduction reactions, providing physiological activity without compromising structural integrity

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The compound can autonomously undergo oxidation-reduction reactions in the body, converting between oxidized and reduced forms without requiring external enzymatic assistance. This self-service capability enhances physiological activity while maintaining compositional stability

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Pantethine trisulfide demonstrates physiologically active functions including vasodilation, anti-inflammatory, neuroprotective, and cardioprotective effects, as well as hydrogen sulfide elimination, through its oxidation-reduction ability and conversion into pantethine persulfide.

Implementation Method 1

Trisulfide compounds are expected to have various physiologically active functions because they have oxidation-reduction ability depending on the possible valence of constituent sulfur atoms

Methodology Applied

Scientific EffectOxidation-reduction reaction: Redox Reactions

Implementation Method 2

pantethine trisulfide is also expected to react in vivo with hydrogen sulfide or cysteine residues of proteins and be converted into pantethine persulfide

Methodology Applied

Scientific EffectChemical bonding: Chemical Bonding