Lactobacillus paracasei vesicles for respiratory disease treatment
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Solution Overview
Problem
Current treatments for viral infectious diseases and respiratory diseases often come with side effects, and there is a lack of effective solutions using vesicles derived from beneficial bacteria like Lactobacillus paracasei for preventing or treating these conditions.
Innovation Solution
The use of vesicles derived from Lactobacillus paracasei as an active ingredient in pharmaceutical, food, inhalant, and cosmetic compositions to prevent or treat viral infectious diseases and respiratory diseases, administered orally or inhaled, which are shown to suppress viral replication and disease symptoms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If steroidal or non-steroidal compositions are used to treat inflammatory diseases, then anti-inflammatory effect is improved, but side effects increase
Solution Approach 1:
The patent uses bacterial extracellular vesicles as an intermediary substance that mediates immune regulation without directly suppressing inflammation like traditional anti-inflammatory drugs. These vesicles act as natural messengers that modulate the immune system's response, providing anti-inflammatory effects through biological regulation rather than direct chemical suppression, thereby avoiding the harmful side effects of steroidal and non-steroidal anti-inflammatory medications.
Solution Approach 2:
The bacterial extracellular vesicles enable the immune system to self-regulate by delivering bioactive molecules that stimulate or modulate endogenous immune responses. Rather than externally forcing anti-inflammatory action, the vesicles help the body's own immune system maintain balance, reducing reliance on external pharmaceutical interventions and their associated side effects.
2Object-affected harmful factors
If conventional treatments are used for viral infectious diseases, then disease symptoms are suppressed, but immune dysfunction is worsened
Solution Approach 1:
The patent converts the potential harm of immune overactivation during viral infection into a benefit by using bacterial vesicles to regulate and balance the immune response. The vesicles contain bioactive molecules that can modulate excessive immune reactions, turning the harmful inflammation into a controlled, beneficial immune regulation that protects against both viral damage and immune-mediated pathology.
3Productivity
If bacteria-derived vesicles are used instead of living bacteria, then absorption rate is improved, but risk of side effects increases
Solution Approach 1:
The patent extracts only the beneficial functional components (extracellular vesicles) from living bacteria, separating them from the whole bacterial cell. This extraction allows the vesicles to be absorbed more efficiently without the risks associated with live bacterial administration, such as uncontrolled replication or pathogenic effects. The vesicles retain the immunomodulatory functions while removing the harmful potential of living bacteria.
Data Source
AI summary
Provided is a method for preventing, alleviating, or treating a viral infectious disease or a respiratory disease, comprising administering a composition containing vesicles derived from Lactobacillus paracasei as an active ingredient to a subject in need thereof, wherein the vesicles may be orally administered and delivered to the lung to suppress a respiratory disease, administered to a COVID-19 virus- or influenza virus-infected model to suppress the replication of the COVID-19 virus and clinical symptoms caused by the influenza virus.