Microorganism Detection Apparatus with Parallel Analyte Capture Channels
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Solution Overview
Problem
Current methods for processing samples to detect microorganisms are laborious and time-consuming, lacking efficient devices for simultaneous processing of multiple samples.
Innovation Solution
An apparatus with a body having reservoirs and channels configured to hold and process analyte capture elements, allowing liquid samples to pass through and capture target analytes, which can then be ejected and detected, facilitating rapid concentration and detection of microorganisms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional pre-treatment methods are used to process samples, then microorganisms can be concentrated and detected, but the process is laborious and time-consuming
Solution Approach 1:
The device segments the sample processing function into multiple independent channels, each capable of processing a sample independently. This modular architecture allows parallel processing of multiple samples simultaneously, reducing total preparation time while maintaining detection precision for each individual sample
Solution Approach 2:
The analyte capture element is pre-loaded into the device and positioned within the channel before sample application. This preliminary positioning eliminates the need for post-sample manipulation and enables immediate capture of target analytes as the sample flows through, significantly reducing processing time
2Measurement precision
If traditional pre-treatment methods are used to process samples, then microorganisms can be concentrated and detected, but the process requires multiple laborious steps
Solution Approach 1:
The device merges multiple pre-treatment functions (filtration, concentration, and analyte capture) into a single integrated system. The analyte capture element performs multiple functions simultaneously - filtering the sample, concentrating target microorganisms, and preparing them for detection - thereby reducing the number of discrete steps required
Solution Approach 2:
The analyte capture element is designed as a multi-functional component that can handle various sample types and detect different microorganisms. This universal design allows a single device to perform diverse diagnostic functions without requiring multiple specialized processing steps for different sample types
3Productivity
If multiple samples are processed simultaneously using traditional methods, then throughput increases, but the lack of efficient devices makes the procedure difficult
Solution Approach 1:
The device incorporates multiple parallel channels, each with its own analyte capture element and flow path. This segmentation allows independent processing of multiple samples simultaneously within a single device, increasing throughput while maintaining simple operation through standardized sample application and processing procedures
Solution Approach 2:
The device is designed to automatically guide the sample through the processing steps without requiring manual intervention at each stage. The fluid flow system self-regulates to deliver samples through the capture elements, and the device structure naturally prevents cross-contamination between channels, making simultaneous multi-sample processing easy to operate
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The apparatus enables efficient processing and concentration of analytes, reducing sample preparation time and improving the detection of microorganisms in samples, suitable for various detection methods.
Implementation Method 1
contacting the liquid sample with the analyte capture element... substantially all liquid passing through the flow path... passes through the analyte capture element
Data Source
AI summary
An apparatus and an assembly for processing a sample are provided. The apparatus comprises a plurality of spaced-apart reservoirs, a plurality of channels, and a plurality of outlets, each outlet comprising an effluent discharge opening. The apparatus forms a plurality of flow paths, each flow path comprising a reservoir, a channel, and an outlet. An analyte capture element can be slideably engaged in a channel in a position where it is in fluid communication with the flow path. The apparatus with the analyte capture element disposed in the flow path can be used to process a liquid sample. A method of detecting an analyte in the liquid sample is also provided.