Parenteral Trace Element Composition for Intensive Care
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Solution Overview
Problem
Current trace element compositions for parenteral nutrition fail to adequately meet the specific requirements of intensive care patients, particularly in terms of selenium and zinc supplementation, leading to imbalances and deficiencies, and do not allow for separate administration of macro and trace elements to match individual patient needs.
Innovation Solution
A nutrition composition providing a daily dosage of 0.04 mg-2.0 mg of selenium and/or 10.0 mg-100 mg of zinc, with a higher concentration ratio of selenium to chromium and zinc to chromium compared to existing preparations, and excluding iron, formulated as an infusion solution for parenteral administration, allowing for flexible dosing and separate administration of trace elements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If trace element compositions are formulated with standard concentrations of selenium and zinc, then general nutritional requirements are met, but intensive care patients experience deficiencies and imbalances
Solution Approach 1:
The patent divides the trace element supplementation into separate administrable compositions - one containing selenium and another containing zinc. This allows clinicians to administer different combinations and dosages tailored to individual patient needs, resolving the contradiction between meeting general requirements and adapting to individual needs.
Solution Approach 2:
The patent enables dynamic adjustment of trace element dosages by providing separate compositions that can be administered in varying amounts based on patient condition, laboratory values, and clinical response. This dynamic approach allows the supplementation regimen to adapt to changing patient requirements.
2Ease of operation
If macro and trace elements are administered together in fixed ratios, then administration is simplified, but flexibility to adjust dosages is lost
Solution Approach 1:
The patent segments the trace element administration into separate compositions for selenium and zinc, which can be administered independently. This maintains simplicity by providing ready-to-use compositions while enabling flexible dosing adjustments based on patient needs.
Solution Approach 2:
The patent creates universal compositions that can serve multiple functions - each composition can be administered alone or in combination with others, allowing for simplified administration while maintaining the ability to adjust dosages flexibly based on individual patient requirements.
3Reliability
If iron is included in trace element compositions, then iron deficiency is addressed, but it may promote bacterial growth in intensive care patients
Solution Approach 1:
The patent extracts iron from the trace element composition intended for intensive care patients, removing the harmful factor that could promote bacterial growth while maintaining the beneficial trace elements (selenium and zinc) that address deficiency without the associated risk.
Solution Approach 2:
The patent converts the potential harm of iron supplementation into a benefit by selectively omitting iron from compositions designed for intensive care patients, while providing other essential trace elements that do not carry the same risk of promoting bacterial growth.
Data Source
AI summary
The present invention relates to a composition with trace elements for nutrition. The composition is characterized by an increased content of selenium and/or zinc as a trace element.