Partially Acylated Protein Supramolecular Assemblies for Skin Penetration
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Solution Overview
Problem
Current cosmetic and pharmaceutical formulations for skin rejuvenation and post-operative tissue regeneration lack adaptability to individual bodies and do not effectively address the specific challenges of skin aging, cellulite, and scar tissue healing, particularly due to the limitations of collagen and hyaluronidase enzymes in penetrating the skin and maintaining dynamic equilibrium.
Innovation Solution
A cosmetological and pharmaceutical formula containing liposomes with partially acylated proteins, including insulin, collagenase, and hyaluronidase, which form supramolecular assemblies that can be used alone or in combination, facilitating skin rejuvenation, anti-cellulite properties, and enhanced post-operative tissue regeneration by modifying the proteins to 0-10% of their mass, and utilizing ultrasonication and reverse phase methods for production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high molecular weight collagen and hyaluronidase are used in cosmetic formulations, then the theoretical regenerative effect is improved, but the penetration ability through skin barrier deteriorates
Solution Approach 1:
The patent segments high molecular weight collagen into low molecular weight peptides through controlled hydrolysis. This segmentation reduces the molecular size from micrometer scale to nanometer scale, enabling penetration through the skin barrier while retaining the regenerative bioactivity of the original collagen structure
Solution Approach 2:
The patent changes the molecular weight parameter of collagen from high molecular weight to low molecular weight through enzymatic hydrolysis. This parameter transformation maintains the essential amino acid sequence and bioactive properties while achieving the necessary size reduction for skin penetration
2Reliability
If enzymes are used to break down collagen cross-links, then the regenerative activity is improved, but the stability of the enzyme in formulation deteriorates
Solution Approach 1:
The patent uses liposomes as intermediary carriers to protect enzymes from denaturation and degradation in the formulation environment. The liposomal membrane acts as a protective barrier, maintaining enzyme stability while enabling controlled delivery to the target site where regenerative activity is needed
Solution Approach 2:
The patent creates a composite system combining enzymes with liposomal structures. This composite material provides both the regenerative activity of enzymes and the stability of liposomal encapsulation, resolving the contradiction between activity and stability
3Adaptability or versatility
If proteins are modified through acylation, then the adaptability to individual bodies is improved, but the complexity of production process increases
Solution Approach 1:
The patent modifies protein parameters through controlled acylation reactions, changing the chemical properties to enhance adaptability. This parameter modification is achieved through standardized chemical protocols that balance customization with production feasibility
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formula effectively rejuvenates the skin, speeds up post-operative tissue regeneration, and reduces scars by adapting to individual bodies, improving skin elasticity and regeneration processes, while avoiding the limitations of high molecular weight collagen and hyaluronidase in penetrating the skin and maintaining dynamic equilibrium.
Implementation Method 1
containing liposomes with proteins, distinct in that in the capacity of the protein, a system is used based on partially acylated hyaluronidase, insulin, and collagenase
Implementation Method 2
utilizing ultrasonication and reverse phase methods for production
Implementation Method 3
utilizing ultrasonication and reverse phase methods for production
Data Source
AI summary
A cosmetic and pharmaceutical formulation for rejuvenation and restoration of the skin, and methods of making this formulation. The cosmetic and pharmaceutical formulations comprise liposomes containing partially acylated proteins with a modification level of 0.1 to 10% of their mass, wherein the proteins are present in the form of a supramolecular assembly.