Partially Cured Amniotic Membrane Dressing for Corneal Adhesion
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Solution Overview
Problem
Conventional amniotic membrane dressings for ocular wounds face issues such as discomfort due to hard plastic peripherals, poor adhesion to the cornea, high cost, and limited use due to patient rejection, as well as instability on the eye surface, limiting their application in treating ocular surface diseases.
Innovation Solution
A method for manufacturing a partially cured contact lens-type amniotic membrane dressing by placing an amniotic membrane on a mold corresponding to the eye's curvature, drying it, and partially curing the peripheral portion with a crosslinking agent, ensuring excellent biocompatibility, transparency, and tensile strength.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a lens type dressing with plastic ring is used, then fixability and convenience are improved, but patient comfort deteriorates due to foreign object sensation
Solution Approach 1:
The patent applies parameter changes by transitioning the material state of the peripheral portion from uncured (soft) to partially cured (semi-rigid). This partial curing process modifies the physical and chemical properties of the amniotic membrane periphery, enabling it to maintain shape and adhere to the cornea without requiring hard plastic rings, thus resolving the contradiction between fixability and patient comfort
Solution Approach 2:
The patent creates a composite structure where the central portion remains as natural amniotic membrane while the peripheral portion undergoes partial curing to form a different material state. This composite approach allows the periphery to provide structural support and adhesion while the central portion maintains biocompatibility, eliminating the need for foreign plastic materials
2Ease of manufacture
If a disc type dressing is used, then price and patient acceptance are improved, but stability on eye surface deteriorates due to lack of fixation
Solution Approach 1:
The patent applies parameter changes by partially curing the peripheral portion of the amniotic membrane to alter its physical properties. This partial curing enhances the mechanical strength and adhesive properties of the periphery, enabling the disc-type dressing to maintain stability on the eye surface without requiring sutures or complex fixation mechanisms, thus maintaining price competitiveness while improving stability
3Strength
If peripheral portion is fully cured, then structural strength is improved, but biocompatibility and growth factor secretion deteriorate
Solution Approach 1:
The patent applies local quality by differentiating the treatment between the central and peripheral portions of the amniotic membrane. The peripheral portion undergoes partial curing to provide structural strength and adhesion, while the central portion remains uncured to maintain biocompatibility and growth factor secretion. This localized differentiation resolves the contradiction between structural strength and biocompatibility
Solution Approach 2:
The patent applies parameter changes by controlling the degree of curing in the peripheral portion. Instead of full curing, partial curing is achieved by controlling crosslinking agent exposure time and concentration, thereby obtaining optimal balance between structural strength enhancement and preservation of biological functionality
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The partially cured contact lens-type amniotic membrane dressing offers improved biocompatibility, transparency, tensile strength, and growth factor secretion, effectively promoting corneal wound regeneration and addressing the limitations of existing dressings, making it suitable for treating ocular diseases.
Implementation Method 1
a step of filling the chamber with a crosslinking agent so that only a peripheral portion of the amniotic membrane is immersed in the crosslinking agent, and partially curing the peripheral portion of the dried amniotic membrane
Data Source
AI summary
The present invention relates to a contact lens-type dressing manufactured by using a partially cured amniotic membrane dressing and a method of manufacturing same. The method of manufacturing a partially cured contact lens-type amniotic membrane dressing, and the partially cured contact lens-type amniotic membrane dressing of the present invention have a simple manufacturing method, can produce a contact lens-type amniotic membrane without foreign matter, have excellent biocompatibility, have excellent lens compatibility such as transparency and tensile strength compared to a fully cured contact lens-type amniotic membrane dressing, and also have excellent wound healing effects, and therefore, can be effectively used for the treatment of eye diseases such as corneal damage.