Particle Analyzer Dynamic Measuring Time for Low Concentration Samples
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Solution Overview
Problem
Particle analyzers face challenges in accurately measuring low concentration particle samples, particularly in peripheral blood samples, due to insufficient sample volume and concentration, leading to decreased measurement accuracy.
Innovation Solution
A particle analyzer and method that extend the measuring time for low concentration samples, allowing more particles to be measured by mixing the sample with a reagent, incubating, and passing it through a measuring system for a longer duration, thereby increasing the sample volume and improving accuracy without altering the dilution ratio.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If the measuring time is extended for low concentration samples, then the number of particles measured increases and measurement accuracy improves, but the measurement efficiency decreases
Solution Approach 1:
The particle analyzer dynamically adjusts the measuring time based on the concentration of particles in the sample. For low concentration samples, the measuring time is automatically extended to allow sufficient particles to pass through the measuring region, while for normal concentration samples, the standard measuring time is maintained. This dynamic adjustment resolves the contradiction by adapting the measurement duration to the specific sample conditions.
Solution Approach 2:
The system changes the measuring time parameter according to the detected particle concentration. When low concentration is detected, the measuring time is increased to improve measurement accuracy. This parameter change allows the system to maintain high accuracy for low concentration samples without permanently reducing measurement efficiency for all samples.
2Measurement precision
If the sample volume is increased to improve measurement accuracy, then more particles are measured, but the measurement time must be extended
Solution Approach 1:
The system dynamically adjusts both sample volume and measuring time based on particle concentration. For low concentration samples, it increases the sample volume passed through the measuring region and extends the measuring time proportionally, ensuring sufficient particle counts for accurate measurement while minimizing unnecessary time extension for normal samples.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances measurement accuracy by increasing the number of particles measured, improving the classification and counting of low concentration samples, such as white blood cells, without requiring additional components or altering the existing measurement setup.
Implementation Method 1
an optical system (5), wherein the incubated sample is passed through in a set low concentration sample measuring time
Data Source
AI summary
A method and particle analyzer for measuring a low concentration particles sample disclosed.