Particle Reagent Separation for Rapid Test Accuracy
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Solution Overview
Problem
Rapid tests using particle reagents placed directly on test strips suffer from inaccuracy due to non-simultaneous detachment and dissolution, especially with blood or blood derivatives, and existing methods struggle to accurately quantify substances dissolved in liquids.
Innovation Solution
The particle reagent is placed in a separate container where it reacts with the sample, then transferred to the test device, ensuring a constant concentration and simultaneous contact, which enhances accuracy and stability, particularly when used with protein, polypeptide, or heavy metal-based reagents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If the particle reagent is placed directly on the test strip, then the test is easy to use and can be industrially copied, but the measuring accuracy deteriorates due to non-simultaneous detachment and dissolution of the particle reagent
Solution Approach 1:
The test system is divided into separate components: the test strip and a separate container for the particle reagent. This segmentation allows the particle reagent to be stored separately in a stable dry form and added to the sample just before testing, ensuring simultaneous contact with the analyte while maintaining ease of use through a simple two-component system.
Solution Approach 2:
The particle reagent is prepared in advance in a stable dry form in a separate container. This preliminary preparation allows the reagent to be stored for extended periods without degradation, and then added to the sample immediately before testing to ensure optimal reaction conditions and accurate measurements.
2Measurement precision
If the particle reagent is placed in a separate container, then the stability and measurement accuracy are improved, but the device complexity increases
Solution Approach 1:
A separate container serves as an intermediary component between the user and the test strip. This container holds the particle reagent in a stable dry form and facilitates its addition to the sample, improving measurement accuracy while adding only a simple, manageable component to the overall system.
Solution Approach 2:
The particle reagent is changed from a liquid or gel form to a dry powdered form, which dramatically improves its stability for long-term storage. This parameter change (from wet to dry state) allows the reagent to be stored in a separate container without degradation, enhancing analytical sensitivity while maintaining simple device architecture.
3Ease of operation
If the particle reagent is stored in liquid form, then it can be readily used, but the stability during long-term storage deteriorates
Solution Approach 1:
The particle reagent is stored in a dry powdered form (solid phase) instead of liquid form, which provides exceptional stability during long-term storage. Immediately before testing, the dry powder is added to the liquid sample, where it dissolves and becomes active. This phase transition from solid to liquid ensures both long-term stability and readiness for use.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method allows for more reliable and accurate quantitative measurements by ensuring the particle reagent reacts with the sample in controlled conditions, improving analytical sensitivity and stability, especially for proteins, polysaccharides, and viruses, and enabling longer storage of the reagent in dry form.
Implementation Method 1
the sample placed on the strip moves in the strip system and dissolves the particle reagent by means of liquid flow. After this, the sample and the particle reagent move ahead in the strip system by means of capillary forces
Implementation Method 2
Molecules attached to the membrane structure bind the particle reagent by the sample, thus forming a coloured figure on the membrane
Data Source
AI summary
Disclosed is a method for a rapid test. In accordance with an embodiment, a particle reagent is placed into a separate sample or reagent receptacle or test tube, in which the particle reagent reacts with one or several analytes in the liquid sample, and the particle reagent is put into contact with the rapid test device, in which a visible signal is formed by the particle reagent.