Medical Particle Storage Tube Drug Loading Mechanism
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Solution Overview
Problem
Existing medical micro-particles storage tubes face challenges in loading drugs due to surface tension issues, leading to insufficient drug loading and requiring specialized tools for implantation, especially for millimeter-sized particles.
Innovation Solution
A medical micro-particles storage tube with a holding part and a drug delivery part, featuring a two-stage or three-stage structure to facilitate drug solution entry into micro-particles using pressure differences and air-liquid path isolation, allowing for efficient drug loading and implantation with conventional needles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If micro-particles with micrometer-sized holes are used for drug delivery, then precise control of drug release and ability to be implanted into body tissues is improved, but drug loading capacity deteriorates due to surface tension preventing drug liquids and suspensions from entering the particles
Solution Approach 1:
The patent extracts the drug loading function from the implantation function by introducing a separate storage tube structure. The storage tube has a larger inner diameter than the puncture needle, allowing drug liquids to be loaded into the micro-particles outside the needle, while the puncture needle only performs the implantation function. This resolves the contradiction by separating the two functions that previously conflicted with each other.
Solution Approach 2:
The storage tube acts as an intermediary device between the drug source and the micro-particles. It provides a transition zone where drug liquids can be introduced and then transferred to the micro-particles without the constraints of the narrow puncture needle pathway, thereby enabling sufficient drug loading while maintaining the ability to deliver micro-particles through the needle.
2Ease of operation
If millimeter-sized micro-particles are used for implantation, then easier handling and delivery is improved, but device complexity increases due to need for special delivery tools
Solution Approach 1:
The storage tube is designed to work with conventional puncture needles, making the system compatible with existing medical equipment. The storage tube serves multiple functions: storing micro-particles, loading drugs, and interfacing with standard needles. This universal design allows millimeter-sized particles to be handled easily while avoiding the need for specialized complex delivery tools.
3Ease of operation
If conventional puncture needles are used for micro-particle implantation, then ease of operation is improved, but drug loading capacity deteriorates due to narrow needle path
Solution Approach 1:
The system is segmented into two distinct components: a storage tube for drug loading and a puncture needle for implantation. The storage tube has a larger diameter suitable for drug loading, while the puncture needle maintains its conventional narrow path for easy implantation. This segmentation allows each component to be optimized for its specific function without compromise.
Solution Approach 2:
The drug loading action is performed preliminarily in the storage tube before implantation. Micro-particles are loaded with drugs in the storage tube while it is connected to the puncture needle, but the drug loading process occurs in the larger-volume storage tube rather than through the narrow needle path. This preliminary action in a more favorable environment enables sufficient drug loading while maintaining conventional needle implantation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution increases drug loading capacity, simplifies the loading process, and enables precise implantation of micro-particles with different drugs, promoting synergistic effects and controlled release, while being suitable for sterilization and storage.
Implementation Method 1
facilitate drug solution entry into micro-particles using pressure differences
Implementation Method 2
air-liquid path isolation
Data Source
AI summary
A particle storage tube (100) used for implanting microparticles into a body in cooperation with a puncture needle (500), and comprising an accommodation portion (1) and a drug delivery portion (2). The accommodation portion (1) is an elongated hollow tube having a channel (10) used to accommodate microparticles (4). One end of the accommodation portion (1) is connected to the drug delivery portion (2), and the other end of the accommodation portion (1) is an open part (11) used to discharge the microparticles out of the particle storage tube (100). The inner diameter of the channel (10) is 1.0-1.8 times the inner diameter of a lumen (502) of the puncture needle (500). An inner chamber (20) of the drug delivery portion (2) is in communication with the channel (10), and is used for delivering liquid medicine (200) to the channel (10).