Bacteriophage Pas-MUP-1 for Pasteurella multocida Infection Control
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Solution Overview
Problem
Current methods for preventing and treating Pasteurella multocida infections in livestock are inadequate due to the emergence of antibiotic-resistant strains and environmental concerns, necessitating a novel, environmentally friendly approach.
Innovation Solution
A Myoviridae bacteriophage Pas-MUP-1, isolated from nature and specifically effective against Pasteurella multocida, is used as an active ingredient in a composition to prevent and treat infections, offering high specificity and reduced side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antibiotics are used to prevent and treat Pasteurella multocida infections, then treatment effectiveness is improved, but antibiotic resistance develops and environmental harm increases
Solution Approach 1:
The patent uses bacteriophage as an intermediary agent to treat Pasteurella multocida infections. Instead of directly applying antibiotics that cause resistance and environmental harm, the bacteriophage serves as a mediator that selectively infects and lyses the target bacteria through its natural lytic cycle, eliminating the pathogen without the harmful side effects of conventional antibiotics
Solution Approach 2:
The patent replaces the chemical mechanism of antibiotics with a biological mechanism. Instead of using chemical substances that kill bacteria through metabolic disruption, the invention employs bacteriophage that naturally infect and replicate within bacterial cells, ultimately causing cell lysis through a biological process rather than chemical action, thereby avoiding antibiotic resistance
2Adaptability or versatility
If universal antibiotics are used for therapeutic use, then broad coverage is achieved, but normal microflora is disturbed and environment is polluted
Solution Approach 1:
The patent applies the principle of local quality through the high host specificity of bacteriophage. Each bacteriophage strain is designed to infect only specific bacterial hosts through recognition of particular surface receptors, allowing targeted elimination of pathogenic Pasteurella multocida while leaving other bacteria including beneficial microflora completely unaffected. This localized action replaces the universal, non-selective approach of broad-spectrum antibiotics
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bacteriophage composition effectively inhibits and kills Pasteurella multocida cells, providing a specific and environmentally friendly solution for disease prevention and treatment in livestock, reducing the risk of antibiotic resistance and side effects.
Implementation Method 1
Once bacteriophage infects bacteria, the bacteriophage is proliferated in the inside of the bacterial cell. After proliferation, the progenies destroy the bacterial cell wall to escape from the host, suggesting that the bacteriophage has the killing ability of bacteria.
Data Source
AI summary
The present invention relates to: Myoviridae bacteriophage Pas-MUP-1 (accession number KCTC 12706BP) which has the capability to specifically destroy Pasteurella multocida, is characterized by having a genome represented by SEQ ID NO: 1, and is isolated from nature; and a method for preventing and treating Pasteurella multocida infections, using a composition containing bacteriophage Pas-MUP-1 as an active ingredient.