Passion Fruit Extract Neuroprotection Against Oxidative Stress
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Solution Overview
Problem
Current treatments for neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS are inadequate, and there is a need for new, safe, and efficacious interventions to prevent or mitigate neural cell damage and degeneration, particularly given the increasing incidence of these conditions with aging.
Innovation Solution
The use of neuroprotective passion fruit extracts, specifically from cultivars like 428 and PD, which are rich in volatile constituents such as 3-mercaptohexyl acetate, are administered as botanical raw materials or nutraceuticals to protect neural cells from damage and deterioration, reducing oxidative stress and glutamate toxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for neurodegenerative diseases, then some therapeutic effect is achieved, but the treatments are inadequate and do not sufficiently prevent or mitigate neural cell damage and degeneration
Solution Approach 1:
The patent changes the chemical composition parameters of the treatment by using passion fruit extracts rich in volatile constituents (3-mercaptohexyl acetate, 3-mercaptohexyl butanoate, 3-mercaptohexyl hexanoate) instead of conventional treatments. This parameter change in chemical composition provides superior neuroprotective effects by reducing oxidative stress and glutamate toxicity more effectively than existing treatments.
Solution Approach 2:
The patent utilizes passion fruit, an edible fruit that is readily available and inexpensive, to create a neuroprotective treatment. This approach replaces expensive and complex conventional neuroprotective agents with a natural, affordable extract that can be derived from commonly consumed fruit, making the treatment more accessible and cost-effective.
2Ease of operation
If passion fruit extracts are used to protect neural cells, then neuroprotective effects are achieved by reducing cell death and improving cell viability, but further research is needed to determine optimal dosing and long-term efficacy
Solution Approach 1:
The patent performs preliminary in vitro experiments using HT-4 neuronal cells to demonstrate the neuroprotective effects of passion fruit extracts before clinical application. These preliminary studies show that the extracts reduce cell death and improve cell viability, providing a foundation for future clinical trials and helping to establish optimal dosing regimens more efficiently.
Data Source
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AI summary
Methods for the treatment and prevention of neural cell and neuro-pathological disorders are provided, comprising contacting the neural cells, or administering to a subject in need thereof, botanical raw material (BRM) or an extract obtainable from passion fruits. Compositions, as well as a nutraceutical composition comprising the same are also provided.