Transdermal Patch Adhesive Layer with Lactic Acid and Magnesium Aluminometasilicate
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Solution Overview
Problem
Conventional patch preparations face challenges with adhesive layer cohesive force and skin permeability, particularly in the presence of water, where adhesiveness decreases due to sweating and liquid components can transfer, leading to detachment issues.
Innovation Solution
Incorporating lactic acid and magnesium aluminometasilicate into the adhesive layer, with lactic acid at 0.1-10 wt% and magnesium aluminometasilicate at 0.03-7 parts by weight, enhances both adhesive force and skin permeability, preventing detachment in wet conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If lactic acid is added to the adhesive layer to enhance skin permeability, then skin permeability of drug is improved, but adhesiveness decreases in the presence of water
Solution Approach 1:
Magnesium aluminometasilicate acts as an intermediary substance that mediates between lactic acid and water. It absorbs excess water and sweat components, preventing water from interfering with the adhesive bonds between lactic acid and skin, thereby maintaining adhesiveness while allowing lactic acid to enhance drug permeability
Solution Approach 2:
The adhesive layer uses a composite material system combining lactic acid (for skin permeability enhancement) with magnesium aluminometasilicate (for water resistance). This composite structure allows both functionalities to coexist - lactic acid provides permeability improvement while magnesium aluminometasilicate provides water resistance, resolving the contradiction between these two properties
2Strength
If adhesive layer is crosslinked to improve cohesive force, then cohesive force is improved, but adhesiveness decreases in the presence of sweat
Solution Approach 1:
Magnesium aluminometasilicate serves as a protective intermediary that shields the crosslinked adhesive structure from sweat components. It absorbs sweat and prevents direct contact between sweat and the adhesive-skin interface, maintaining adhesiveness despite crosslinking that would otherwise reduce sweat resistance
Solution Approach 2:
The invention changes the chemical composition parameters of the adhesive layer by incorporating magnesium aluminometasilicate alongside the crosslinked adhesive. This parameter modification transforms the adhesive system from one that is either crosslinked (strong cohesive force but poor sweat resistance) to one that has both crosslinking and magnesium aluminometasilicate (maintaining both cohesive force and sweat resistance)
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch preparation maintains adhesiveness and skin permeability of drugs even in the presence of water, providing a superior solution for both properties compared to conventional methods.
Implementation Method 1
The patch preparation of the present invention can enhance a skin permeation effect of a drug, since the adhesive layer contains the drug and lactic acid
Implementation Method 2
the patch preparation of the present invention can suppress a decrease in the adhesiveness of the patch preparation in the presence of water, and can suppress detachment from the skin and the like, since the adhesive layer further contains magnesium aluminometasilicate
Data Source
AI summary
The problem of the present invention is to provide a patch preparation containing a drug (excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof), which is superior in both the skin permeability of a drug, and adhesiveness in the presence of water. A patch preparation containing a support and an adhesive layer on one surface of the support, wherein the adhesive layer contains a drug excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid and magnesium aluminometasilicate.