Transdermal Patch Depot Layout for Reduced Coating Waste

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Solution Overview

Problem

Transdermal therapeutic systems with non-rectangular active ingredient depot geometries face inefficiencies in utilizing the active ingredient-containing coating, leading to significant waste and increased costs due to the inability to arrange and separate depot areas optimally, resulting in unused areas that cannot be utilized as active ingredient depots.

Innovation Solution

The method involves arranging active ingredient depot areas in parallel rows on a coated carrier film web such that they can be separated without cutting, ensuring none are cut during the process, and optimizing the cutting of the film web into partial webs to maximize the use of the coating, with the option to adjust the position of partial webs to facilitate further processing without overlapping.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If non-rectangular active ingredient depot areas (e.g., circular) are arranged next to each other, then the manufacturing process becomes simpler, but the loss of active ingredient-containing coating increases to almost 22% or up to 39%

Engineering Contradiction:

Improveease of manufactureVSAvoidloss of active ingredient-containing coating

Core Design Contradiction:

Ease of manufactureVSLoss of substance

Solution Approach 1:

The patent divides the carrier film web into multiple partial webs in the web direction, allowing different arrangements of active ingredient depot areas in each partial web. This segmentation enables optimization of space utilization while maintaining manufacturing simplicity for non-rectangular depot geometries.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent utilizes the web direction (longitudinal dimension) of the carrier film to arrange multiple rows of active ingredient depot areas, transforming the problem from a two-dimensional planar arrangement to a three-dimensional spatial optimization that reduces waste.

Inventive Principle:

Principle #17Another dimension (Dimensionality change)

2Loss of substance

If multiple rows of active ingredient depot areas are arranged in the web direction, then the utilization of the coated carrier film improves, but the complexity of separating and processing the depot areas increases

Engineering Contradiction:

Improveloss of active ingredient-containing coatingVSAvoidcomplexity of separation and processing

Core Design Contradiction:

Loss of substanceVSDevice complexity

Solution Approach 1:

The carrier film web is divided into multiple partial webs that can be separated and processed independently. Each partial web contains a series of active ingredient depot areas arranged in rows, simplifying the overall separation and processing complexity.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The active ingredient depot areas are pre-formed on the carrier film in the desired arrangement before separation into partial webs. This preliminary arrangement optimizes space utilization while facilitating subsequent easy separation and processing.

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentEP2804734B2Reduced loss of lattice material in patch manufacturing

Publication Date: 2025.01.15 LUYE PHARMA AG

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AI summary

The invention relates to methods for producing systems for the transdermal or permucosal administration of active substances, particularly transdermal therapeutic systems (TTS), wherein the active substance depots thereof have a shape that deviates from a rectangular design.