Transdermal Patch Support with Inorganic Oxide Layer
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Solution Overview
Problem
Conventional transdermal patch preparations face challenges in achieving sufficient drug releasability and anchoring property of the pressure-sensitive adhesive layer while maintaining low moisture permeability, which can affect patch durability and comfort.
Innovation Solution
Incorporating an extremely thin inorganic oxide layer between a polyester base layer and a polyester nonwoven fabric layer in the patch support, enhancing the moisture barrier and anchoring properties of the adhesive layer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a lowly moisture-permeable covering material is used to improve drug releasability through ODT effect, then drug releasability is improved, but the support itself does not provide low moisture permeability and anchoring property is insufficient
Solution Approach 1:
The invention changes the moisture permeability parameter of the support itself by incorporating an inorganic oxide layer, transforming it from a high moisture-permeable state to a lowly moisture-permeable state. This enables the support to directly provide the ODT effect without relying on external covering materials, while simultaneously ensuring the anchoring property of the pressure-sensitive adhesive layer is maintained through proper layer construction.
Solution Approach 2:
The invention uses a composite structure consisting of a polyester base layer combined with an inorganic oxide layer to create a support that inherently possesses low moisture permeability. This composite material approach allows the support itself to provide both the structural foundation and the moisture barrier function, eliminating the need for separate covering materials and ensuring proper anchoring of the adhesive layer.
2Productivity
If the support itself is made lowly moisture-permeable to improve drug releasability, then ODT effect is enhanced, but anchoring property of the pressure-sensitive adhesive layer may be insufficient
Solution Approach 1:
The invention modifies the moisture permeability parameter of the support by integrating an inorganic oxide layer, enabling the support to directly exert the ODT effect. The layer construction and material selection ensure that this parameter change does not compromise the anchoring property of the pressure-sensitive adhesive layer, achieving both low moisture permeability and sufficient anchoring.
Solution Approach 2:
The inorganic oxide layer acts as an intermediary between the polyester base layer and the pressure-sensitive adhesive layer, providing the low moisture permeability needed for ODT effect while maintaining the anchoring property of the adhesive layer through its intermediate position and compatible properties.
3Productivity
If an inorganic oxide layer is added to achieve low moisture permeability, then ODT effect is realized, but the layer may detach due to bending or friction
Solution Approach 1:
The invention uses a thin film structure for the inorganic oxide layer that provides effective moisture barrier properties while maintaining flexibility. This thin film approach allows the layer to bend and flex without cracking or detaching, ensuring durability during patch application and wear while still achieving the desired low moisture permeability for ODT effect.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration results in improved drug releasability, durability, and comfort by maintaining low moisture permeability and preventing the inorganic oxide layer from detaching due to bending or friction, while ensuring excellent anchoring and flexibility of the patch.
Implementation Method 1
the support has a polyester base layer, an inorganic oxide layer, and a polyester nonwoven fabric layer in the stated order... can impart durability to the inorganic oxide layer, and as a result, the inorganic oxide layer can be favorably prevented from dropping off... and can realize the excellent flexibility of the patch preparation
Data Source
AI summary
The present invention provides a patch preparation that has an extremely low moisture permeability, has a sufficient ODT effect, is excellent in drug releasability and in anchoring property of its drug-containing pressure-sensitive adhesive layer, and has a preferred patch feeling. The patch preparation of the present invention includes a support; and a pressure-sensitive adhesive layer containing an adherent polymer and a drug on one surface of the support, wherein: the support has a polyester base layer, an inorganic oxide layer, and a polyester nonwoven fabric layer in the stated order; the polyester base layer has a thickness of 1.0 μm to 16 μm; and the pressure-sensitive adhesive layer is laminated on the polyester nonwoven fabric layer.