Patient-Specific 3D Complex Coils for Cerebral Aneurysm Occlusion

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Solution Overview

Problem

Current endovascular coil designs are sub-optimal for atypical aneurysm morphologies, leading to sub-optimal aneurysm occlusion and potential recurrence due to their inability to accommodate complex shapes and sizes.

Innovation Solution

Patient-specific 3D complex coils made from shape memory alloys like nitinol, designed using digital modeling and 3D printing techniques to match individual aneurysm geometry, allowing for precise customization and optimal occlusion.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If standard endovascular coils are used for atypical aneurysm morphologies, then the treatment procedure is simple and quick, but the aneurysm occlusion is sub-optimal and recurrence risk increases

Engineering Contradiction:

Improveaneurysm occlusion effectivenessVSAvoidcoil design complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

Patient-specific 3D printed models of the aneurysm are created before the procedure to plan and design custom coil configurations that match the unique geometry, allowing optimal coil placement strategy to be determined in advance

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

Coils are customized with specific geometric parameters (diameter, pitch, curvature) tailored to the local morphology of each patient's aneurysm, ensuring optimal fit and occlusion effectiveness for atypical shapes rather than using uniform standard designs

Inventive Principle:

Principle #3Local quality

2Reliability

If patient-specific 3D complex coils are manufactured for each aneurysm, then optimal aneurysmal occlusion is achieved, but the manufacturing process becomes more complex and time-consuming

Engineering Contradiction:

Improveaneurysm occlusion effectivenessVSAvoidcoil manufacturing process

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

Standard coil manufacturing parameters (wire diameter, helix pitch, coil diameter) are adjusted and optimized for each patient-specific case based on the 3D model, allowing customization without completely redesigning the manufacturing process

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patient's unique aneurysm geometry is replicated through 3D printing to create a physical model that serves as a template for coil design and testing, enabling precise customization while streamlining the design process

Inventive Principle:

Principle #26Copying

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Improves treatment outcomes by providing optimal aneurysmal occlusion and reducing long-term complications through customized coil designs that better fit unique aneurysm shapes and sizes, enhancing the effectiveness of endovascular treatment.

Implementation Method 1

Patient-specific 3D complex coils made from shape memory alloys like nitinol

Methodology Applied

Scientific EffectShape memory alloy: Shape Memory Alloy

Data Source

PatentUS10973526B2Customized endovascular devices and methods pertaining thereto

Publication Date: 2021.04.13 THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA

AI summary

Patient-specific 3D complex coils and methods of making and using such coils, including custom fixtures for the manufacture of such coils. Such patient-specific 3D complex coils improve treatment outcomes for cerebral aneurysm repair. The aneurysm may be an aneurysm in a specific patient and/or population of patients having a similar aneurysm shape and size.