Patient-Specific Dermal Regeneration Sheet for Diabetic Foot Ulcers

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Solution Overview

Problem

Existing methods fail to effectively restore skin tissue in diabetic foot ulcers, leading to complications such as partial leg amputations, necessitating a means to treat diabetic foot syndrome and promote skin regeneration.

Innovation Solution

A method involving the extraction of autologous adipose tissue, filtration to remove fibers, crushing to obtain an adipose tissue extract, 3D scanning to create a patient-specific mold, and application of solutions containing adipose tissue extract and fibrinogen/thrombin to form a skin regeneration layer.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional skin regeneration methods are used, then treatment time is extended, but skin restoration effectiveness deteriorates

Engineering Contradiction:

Improveskin restoration effectivenessVSAvoidtreatment time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent prepares adipose tissue extract and creates patient-specific 3D molds in advance before the actual skin regeneration treatment. This preliminary preparation of biological materials and custom fixtures enables rapid treatment execution without compromising restoration effectiveness, directly resolving the contradiction between treatment time and effectiveness.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent creates accurate 3D copies of the patient's skin defect area using scanning technology to manufacture custom molds. This copying approach enables precise fitting and accelerated treatment while maintaining high restoration effectiveness, addressing both time and effectiveness requirements.

Inventive Principle:

Principle #26Copying

2Adaptability or versatility

If generic skin regeneration sheets are used, then manufacturing complexity is reduced, but adaptability to patient-specific defects deteriorates

Engineering Contradiction:

Improvematch to affected areaVSAvoidmanufacturing process complexity

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent manufactures skin regeneration sheets with locally optimized properties by creating patient-specific 3D molds that precisely match the unique geometry of each patient's defect area. This local customization approach maximizes adaptability while the standardized adipose tissue extraction protocol manages manufacturing complexity.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent changes the geometric parameters of the skin regeneration sheet by using 3D scanning and custom molding to match specific patient defects. This parameter customization achieves high adaptability while the automated 3D printing process controls manufacturing complexity.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If adipose tissue is not processed through multiple filtration stages, then manufacturing steps are reduced, but cell activity and growth factor preservation deteriorate

Engineering Contradiction:

Improvecell activity and growth factor effectVSAvoidmanufacturing efficiency

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent segments the adipose tissue processing into distinct filtration stages (first filter for large debris, second filter for intermediate particles, third filter for fine purification). This segmentation preserves cell activity and growth factors by removing contaminants at appropriate stages while maintaining manufacturing efficiency through a systematic multi-step protocol.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent uses a series of filters as intermediary elements between the raw adipose tissue and the final extract. These intermediary filters selectively remove unwanted components while preserving beneficial cells and growth factors, resolving the contradiction between purification effectiveness and manufacturing efficiency.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Rapidly manufactures a patient-specific skin regeneration sheet with high cell activity, ensuring effective restoration of diabetic foot ulcers by promoting skin regeneration and matching the affected area's shape and depth.

Implementation Method 1

obtaining 3D data of the skin defect area of a patient using a 3D scanner

Methodology Applied

Scientific EffectLight reflection: Reflection

Implementation Method 2

curing the proto-layer into a skin regeneration layer by applying a second solution containing thrombin onto the proto-layer

Methodology Applied

Scientific EffectCoagulation: Coagulation

Data Source

PatentUS20260041717A1Method of manufacturing diabetic foot patient-specific dermal regeneration sheet and diabetic foot patient-specific dermal regeneration sheet manufactured using the same

Publication Date: 2026.02.12 ROKIT HEALTHCARE INC

AI summary

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet. The method includes extracting autologous adipose tissue, removing fibers in the autologous adipose tissue, crushing the autologous adipose tissue, and acquiring an adipose tissue extract by filtrating the crushed autologous adipose tissue.