Patterned Indwelling Biosensor Electrodes for Higher CGM Sensitivity
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing continuous glucose monitoring (CGM) devices face issues with non-optimal sensor performance, leading to reduced adoption and durability, necessitating improved sensor characteristics for enhanced accuracy and reliability.
Innovation Solution
A method of constructing an indwelling analyte sensor involves applying a dielectric material to a wire with electrochemically active surfaces, exposing selected regions through techniques like laser-ablation, and coating the remaining areas with a membrane material containing an enzyme layer, such as glucose oxidase, to increase the surface area and sensitivity of the sensor.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a dielectric material is applied to cover the entire wire surface, then the electrical insulation is improved, but the sensitivity and surface area of the electrochemically active surface is reduced
Solution Approach 1:
The patent applies local quality by selectively removing the dielectric material from specific regions of the wire to create exposed electrochemically active surfaces. This allows different parts of the wire to have different properties: covered regions provide electrical insulation while exposed regions provide sensitivity for analyte detection. The dielectric material is removed in patterns that create cavities or grooves, exposing the electrochemically active surface only where needed for sensing.
2Measurement precision
If the sensor surface area is increased to improve sensitivity, then the detection capability is enhanced, but the sensor size and complexity increase
Solution Approach 1:
The patent utilizes the third dimension by creating cavities or grooves that extend into the wire surface, thereby increasing the effective surface area within a compact footprint. The dielectric material is removed to create three-dimensional features such as cavities with patterned electrochemically active surfaces, allowing the sensor to achieve high sensitivity without proportionally increasing the overall sensor dimensions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patterned sensor design enhances sensitivity by 2-3 times, improving sensor performance and response, thereby addressing the limitations of existing CGM devices.
Implementation Method 1
removing one or more selected regions of the applied dielectric material to expose one or more electrochemically active surfaces of the electrochemically active surfaces of the wire
Implementation Method 2
the membrane material comprising an enzyme layer
Implementation Method 3
the enzyme layer comprises a glucose oxidase layer
Data Source
AI summary
Embodiments provide for an analyte sensors and methods of construction thereof. In one example, a method of constructing an indwelling analyte sensor comprises coating a wire with a dielectric material, removing one or more regions of the dielectric material to expose one or more electrochemically active surface(s), producing a pattern in the one or more exposed electrochemically active surfaces to increase surface area of the one or more electrochemically active surfaces, and coating remaining regions of dielectric material and the one or more exposed electrochemically active surfaces with a membrane material comprising an enzyme layer. In this way, sensor response and performance can be improved with corresponding reductions in in-skin sensor length.