Photobiomodulation Light Dosing With Metabolic Feedback Control
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Solution Overview
Problem
Existing PBM therapies are inefficient due to unoptimized treatment parameters and lack of methods to monitor metabolic activity, leading to bimodal effects and limited clinical use.
Innovation Solution
A device and method that control light dosimetry, spectroscopy, and illumination duration to induce optimal PBM effects by identifying and targeting 'hot spots' within biological tissues, using feedback from metabolic activity monitoring to adjust fluence rate, wavelength, and illumination time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If PBM therapy is applied with conventional parameters, then treatment can be performed, but treatment parameters are not optimized leading to bimodal effects and limited efficacy
Solution Approach 1:
The patent implements feedback control by monitoring metabolic activity parameters (such as oxygen consumption, ATP production, or other biomarkers) during PBM treatment and using this information to dynamically adjust treatment parameters including fluence rate, illumination duration, and wavelength selection. This closed-loop approach ensures optimal treatment effects while avoiding bimodal responses.
Solution Approach 2:
The patent systematically varies multiple PBM parameters simultaneously including fluence rate (irradiance), total fluence (illumination duration), wavelength selection, and spatial distribution patterns. By optimizing these parameters based on feedback from metabolic monitoring, the patent achieves superior treatment efficacy compared to conventional fixed-parameter approaches.
2Reliability
If PBM therapy parameters are optimized, then treatment efficacy is improved, but device complexity increases due to need for monitoring and control systems
Solution Approach 1:
The patent incorporates feedback mechanisms that monitor metabolic activity parameters during treatment and automatically adjust PBM parameters accordingly. This reduces the need for complex manual control systems and expert intervention, as the system self-regulates based on real-time physiological responses.
Solution Approach 2:
The treatment system performs self-optimization by automatically adjusting fluence rate, duration, and wavelength based on real-time metabolic monitoring data. The system serves itself by using the monitored physiological responses to automatically tune treatment parameters, reducing the burden on operators and simplifying the overall control architecture.
3Reliability
If treatment parameters are optimized for specific tissues, then PBM effects are enhanced, but adaptability to different biological objects is reduced
Solution Approach 1:
The patent employs dynamic adjustment of treatment parameters including real-time modification of fluence rate, illumination duration, and wavelength selection based on feedback from metabolic monitoring. This dynamic approach allows the same device to adapt to different tissue types, depths, and physiological states, maintaining optimal efficacy across diverse applications without requiring separate protocols for each tissue type.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances PBM efficacy by optimizing treatment parameters, improving metabolic activity and tissue regeneration, and addressing conditions like myocardial infarction, systemic inflammation, and metabolic disorders.
Implementation Method 1
a light source (a) comprising at least one light emitting diode (LED)
Implementation Method 2
a light distributor (b) in communication with the light source (a)
Data Source
Figure 1~2
Figure 3
Figure 4a
AI summary
The invention relates to a device for applying Photobiomodulation (PBM) on a biological object comprising a light source delivering light with an adequate temporal evolution of its optical power, said device also comprising a processing and/or a light control unit that determines the adequate temporal evolution of the optical power on the basis of the biological object optical coefficients and the light delivery geometry on/in the biological object, characterized by the fact that the PBM effects are induced by the generation of one or several specific fluence rates during one or several specific times, successively, in each parts of the volume of the biological object. said specific combined fluence rate(s) and said times being selected in the following groups of parameters : 3±2 mW/cm2 during 180±30 s or 11±9 mW/cm2 during 80±25 s or 16±10 mW/cm2 during 40±20 s or 25±10 mW/cm2 during 15±10 s or 10+9,7 mW/cm2 during 40±1 s. The invention also relates to different methods for applying (PBM) on a biological object comprising a light source delivering light with an adequate temporal evolution of its optical power as mentioned above. The invention also relates to device and methods mentioned above for applying PBM that are optionally used or applied with exogenous agents involved in, or modulating, the metabolism. The invention also relates to device and methods mentioned above for applying PBM that are optionally used or applied in combination with probes monitoring the metabolic activity taking place in the biological object. This monitoring enables to define the optimal PBM light applications conditions, in terms of: i) time relative to the metabolic activity, ii) fluence rate and iii) illumination duration.