Intravascular Pd/Pa Cycle Analysis for Stenosis Detection
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing cardiovascular diagnostic techniques, such as intravascular optical coherence tomography (OCT) and ultrasound (IVUS), lack effective methods to simplify and distill diagnostic metrics without unnecessary complications, requiring improved diagnostic tools for coronary artery diseases.
Innovation Solution
A computer-based method using a pressure value-based ratio (Pd/Pa) is determined from intravascular data, with a minimum cycle ratio (MCR) identified and plotted over time to provide diagnostic metrics for cardiac cycle events, independent of ECG triggering or landmark identification, enhancing sensitivity to pressure changes during pullback.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional intravascular imaging modalities (OCT, IVUS) are used to collect cardiovascular data, then high-resolution visualization and substantial diagnostic data are obtained, but the data requires complex processing and lacks simplified diagnostic metrics
Solution Approach 1:
The patent extracts and isolates the critical diagnostic element from complex intravascular data by focusing specifically on pressure ratio measurements (Pd/Pa). Instead of processing all available imaging and physiological data, the method extracts only the essential pressure differential information needed to assess stenosis severity, thereby simplifying the diagnostic workflow while maintaining diagnostic accuracy
Solution Approach 2:
The patent transforms complex multivariate intravascular data into a single simplified parameter - the pressure ratio (Pd/Pa). By changing the representation from multiple complex parameters (imaging data, flow data, pressure waveforms) to a single ratio parameter, the system maintains diagnostic sensitivity while dramatically reducing processing complexity
2Reliability
If pressure data is collected during cardiac cycles to diagnose stenosis, then diagnostic information about vessel conditions is obtained, but sensitivity to pressure changes during catheter pullback is reduced without ECG triggering
Solution Approach 1:
The patent employs dynamic analysis of pressure ratios throughout the cardiac cycle rather than static measurements at fixed ECG triggers. By continuously monitoring and analyzing Pd/Pa ratios across multiple cardiac cycles and identifying minimum values, the method captures transient pressure changes that occur during catheter pullback, improving sensitivity without requiring ECG synchronization
Solution Approach 2:
The system uses feedback from multiple cardiac cycles to identify the minimum Pd/Pa ratio values. By comparing pressure ratios across successive cardiac cycles and selecting the minimum values, the method enhances the sensitivity to detect stenosis-induced pressure changes while maintaining diagnostic reliability through cyclic verification
Data Source
AI summary
A method of operating an intravascular data processing system that determines one or more diagnostic metrics for assessing blood vessels using intravascular data includes: receiving, at an intravascular data processing system, a plurality of sampled distal pressure values and a plurality of sampled proximal pressure values; determining, using the intravascular data processing system, a plurality of sets of Pd/Pa ratios based on sampled distal pressure values and sampled proximal pressure values, each of the plurality of sets of Pd/Pa ratios including Pd/Pa ratios that are determined through an entirety of one heart cycle; generating on a display system, using the intravascular data processing system, a plot of the plurality of sets of Pd/Pa ratios over time; and simultaneously displaying, on the plot, a plurality of markers, each located at a minimum Pd/Pa ratio within one of the sets of Pd/Pa ratios over the entirety of the corresponding heart cycle.