PEG-Gélucire Excipient Pellets for Room-Temperature Handling
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Solution Overview
Problem
Gélucire® 44/14, a pharmaceutical excipient, is difficult to handle due to its paste-like form, requiring melting and handling of hot liquids, leading to inefficiencies and potential losses.
Innovation Solution
Combining Gélucire® 44/14 with polyethylene glycol (PEG) at room temperature to create a divisible solid form, allowing for individualized particles such as pellets, which can be easily handled and used in precise quantities.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Gélucire® 44/14 is used as a pharmaceutical excipient, then the dissolution properties of active ingredients are enhanced, but the handling becomes difficult due to its paste-like form requiring melting and handling of hot liquids
Solution Approach 1:
The patent combines Gélucire® 44/14 (lauric macrogolglyceride) with polyethylene glycol (PEG) to create a composite material. This composite maintains the superior dissolution properties of Gélucire® while adding the benefits of PEG, which allows the mixture to be handled as a divisible solid at room temperature rather than as a hot liquid paste, thus resolving the handling difficulty while preserving dissolution enhancement
Solution Approach 2:
The patent changes the physical state parameter of the excipient mixture by combining it with PEG. The composite material can be processed and handled at room temperature in a solid divisible form, eliminating the need to maintain high temperatures during handling while still achieving the desired dissolution properties when the formulation is activated
2Ease of operation
If Gélucire® 44/14 is melted for handling, then it becomes easier to process, but energy consumption increases and potential losses occur
Solution Approach 1:
By formulating a composite of Gélucire® 44/14 and PEG, the patent enables processing at room temperature without requiring melting. The PEG component allows the mixture to be handled as a divisible solid, eliminating the energy-intensive heating and melting steps while maintaining processability through mechanical division and mixing
Solution Approach 2:
The composite material exhibits self-service properties by being inherently processable at room temperature. The mixture can be directly divided, weighed, and incorporated into formulations without requiring external heating or melting equipment, thereby eliminating energy consumption and associated losses
3Reliability
If Gélucire® 44/14 is used in paste form, then dissolution properties are maintained, but precision in quantity handling is reduced
Solution Approach 1:
The Gélucire® 44/14 and PEG composite can be manufactured as divisible solid forms such as pellets or granules with defined sizes and weights. This allows for precise measurement and dosing using standard pharmaceutical equipment, eliminating the imprecision associated with handling paste-like materials while preserving the dissolution-enhancing properties of Gélucire®
Solution Approach 2:
The patent segments the excipient mixture into individual divisible particles or pellets. This segmentation transforms the continuous paste into discrete units that can be accurately counted, weighed, and distributed, thereby achieving precise quantity handling while maintaining the functional properties of the original excipient
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Facilitates easier and more precise handling of Gélucire® 44/14, ensuring homogeneous compositions without the need for melting, and enhances the dissolution properties of active ingredients.
Implementation Method 1
The individualized particles of excipient as described previously are melted to obtain a liquid mass
Data Source
Figure 1~2
Figure 3a
Figure 3b
AI summary
The invention relates to the use, as a pharmaceutical or cosmetic excipient, of a solid composition at room temperature in the form of individualized particles, said composition comprising: - lauric macrogolglyceride, - polyethylene glycol.