PEG-Emulsified Topical Composition for Vitamin B6 Discoloration

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Solution Overview

Problem

Topical compositions containing vitamin B6 or its derivatives, such as pyridoxine hydrochloride, tend to discolor upon storage, leading to an undesirable optical appearance.

Innovation Solution

Incorporating a PEG-emulsifier, optionally combined with hyaluronic acid or its salt, into the topical compositions to suppress discoloration, with sodium hyaluronate further reducing discoloration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If topical compositions are used to treat hair loss, then hair growth may be stimulated, but the compositions often have unpleasant odors, unacceptable colors, or irritating effects on the skin

Engineering Contradiction:

Improvehair growth stimulationVSAvoidunpleasant odor, unacceptable color, skin irritation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts and removes the harmful components (unpleasant odor, unacceptable color, irritating effects) from the topical composition while retaining the beneficial hair growth stimulation properties. This is achieved by carefully selecting and combining specific ingredients that provide therapeutic effects without the adverse characteristics of prior art compositions.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent modifies the chemical and physical parameters of the composition, specifically adjusting pH levels, concentration ratios of active ingredients, and molecular weight characteristics to eliminate unpleasant odor, achieve acceptable color, and reduce skin irritation while maintaining hair growth stimulation efficacy.

Inventive Principle:

Principle #35Parameter changes

2Adaptability or versatility

If conventional topical compositions are formulated, then they may address hair loss, but they fail to provide acceptable odor, color, and skin compatibility simultaneously

Engineering Contradiction:

Improvehair loss treatmentVSAvoidodor, color, irritation

Core Design Contradiction:

Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The patent employs a composite formulation combining multiple natural and synthetic ingredients in specific proportions. This composite approach allows the composition to deliver hair growth stimulation while simultaneously providing acceptable sensory properties (odor and color) and skin compatibility, achieving a balance that conventional single-ingredient or simple mixture formulations cannot attain.

Inventive Principle:

Principle #40Composite materials

Data Source

PatentEP3863598B1Topical composition

Publication Date: 2026.04.29 DSM IP ASSETS BV

AI summary

The present invention is concerned with the use of a PEG-emulsifier, optionally in combination with hyaluronic acid or a salt thereof for suppressing discoloration in topical compositions comprising vitamin B6 or a derivative thereof. Furthermore, the invention relates to a method for reducing discoloration of topical compositions containing vitamin B6 or a derivative thereof, comprising preparing a topical composition comprising vitamin B6, a PEG-emulsifiers and optionally hyaluronic acid and a cosmetically acceptable carrier.