Pelargonium Extract Solubility via Solid Carrier Pre-treatment

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Solution Overview

Problem

Conventional methods for producing dry extracts from Pelargonium sidoides and Pelargonium reniforme result in extracts with excessive solvent content, leading to impaired solubility and difficulties in producing liquid preparations, which affects the effectiveness and handling of these extracts.

Innovation Solution

A process involving the preparation of an aqueous or aqueous-alcoholic solution of the Pelargonium extract, followed by the addition of specific solid carriers like saccharides and sugar alcohols before concentrating and drying, to enhance solubility in physiologically compatible solvents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If direct drying of Pelargonium liquid extracts is performed, then production simplicity is maintained, but solvent content remains excessive and solubility is impaired

Engineering Contradiction:
Improveproduction simplicityVSAvoidsolvent content
Core Design Contradiction:
Ease of manufactureVSQuantity of substance

Solution Approach 1:

The patent applies preliminary action by adding solid carriers (such as sugars, starches, or cellulose derivatives) to the liquid extract before the drying process. This pre-treatment step allows the carriers to bind with the solvent and active ingredients, preventing excessive solvent retention during subsequent drying while maintaining production simplicity. The carriers are incorporated in advance at controlled ratios, ensuring optimal solubility and extraction efficiency without complex post-processing steps.

Inventive Principle:
Principle #10Preliminary action

2Quantity of substance

If solid carriers are added to liquid extracts before drying, then solubility is improved, but process complexity increases

Engineering Contradiction:
ImprovesolubilityVSAvoidprocess complexity
Core Design Contradiction:
Quantity of substanceVSDevice complexity

Solution Approach 1:

The patent utilizes parameter changes by systematically varying the type, amount, and particle size of solid carriers added to the liquid extract. Different carriers (sugars, starches, cellulose derivatives) are tested at various concentrations and addition rates to optimize solubility while maintaining manageable process complexity. The method establishes specific parameter ranges for carrier-to-extract ratios and drying conditions, transforming a potentially complex variable process into a standardized procedure with defined parameters.

Inventive Principle:
Principle #35Parameter changes

3Productivity

If excessive solvent remains in dry extracts, then production efficiency is maintained, but effectiveness of the extract is impaired

Engineering Contradiction:
Improveproduction efficiencyVSAvoideffectiveness
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The patent employs solid carriers as intermediaries between the liquid extract and the final dry product. These carriers (such as sugars, starches, or cellulose derivatives) mediate the transition by binding with both the solvent and active ingredients during the drying process. This intermediary role allows for efficient production while ensuring that excessive solvent does not remain in the final product, thereby maintaining both productivity and extract effectiveness. The carriers facilitate controlled solvent removal without compromising active ingredient integrity.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The process significantly improves the solubility of the dry extracts, allowing them to dissolve completely in solvents, which is advantageous for processing into solid pharmaceutical forms like tablets, ensuring effective active ingredient release.

Implementation Method 1

adding one or more solid carriers, independently selected from the group consisting of fructose, galactose, glucose, xylose, alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, hydroxypropyl betadex, lactose, lactulose, maltose, raffinose, sucrose, trehalose, chitosan, chitosan hydrochloride, dextran, dextrin, guargalactomannan, arabic gum, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, inulin, maltodextrin, methylcellulose, methylhydroxyethylcellulose, polydextrose, erythritol, isomalt, lactitol, maltitol, mannitol, sorbitol and xylitol

Methodology Applied
Scientific EffectDissolution: Solvation

Implementation Method 2

concentrating and drying the resulting extract solution to the dry extract

Methodology Applied
Scientific EffectEvaporation: Evaporation

Implementation Method 3

drying at 50 °C under vacuum (up to 18 mbar)

Methodology Applied
Scientific EffectVacuum drying: Vacuum Distillation

Data Source

PatentEP2134369B1Method for producing dry extracts of pelargonium sidoides and pelargonium reniforme
Publication Date: 2019.01.02 DR WILLMAR SCHWABE GMBH & CO

AI summary

The invention relates to production methods for obtaining dry extracts from Pelargonium sidoides and/or Pelargonium reniforme, extracts obtainable according to said method, and pharmaceutical products comprising such extracts.