Pelvic Pain Composition Using PEA and Pine Extract
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Solution Overview
Problem
Current treatments for chronic and acute pelvic pain often rely on pharmaceuticals with side effects and cannot be used as nutraceuticals due to phytocannabinoid content, limiting their spectrum of action and applicability.
Innovation Solution
A composition comprising micronized palmitoylethanolamide (PEA), refined hemp seed oil substantially free from phytocannabinoids, and maritime pine extract or procyanidins, formulated for oral administration to provide a synergistic anti-inflammatory effect without phytocannabinoids, suitable for both pharmaceutical and nutraceutical use.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If pharmaceuticals are used to treat pelvic pain, then pain relief is achieved, but unwanted side effects occur
Solution Approach 1:
The patent changes the chemical parameters of the treatment by using natural compounds (PEA, procyanidins, fatty acids) instead of conventional pharmaceuticals, thereby maintaining analgesic and anti-inflammatory efficacy while eliminating unwanted side effects associated with synthetic drugs
Solution Approach 2:
The invention combines multiple natural active compounds (palmitoylethanolamide, procyanidins from maritime pine extract, and omega-3/omega-6 fatty acids from hemp seed oil) into a composite formulation that works synergistically to treat pelvic pain without the harmful side effects of conventional pharmaceuticals
2Reliability
If compositions containing phytocannabinoids are used, then anti-inflammatory effect is improved, but the composition cannot be classified as nutraceutical
Solution Approach 1:
The patent extracts and isolates the beneficial anti-inflammatory components (procyanidins from maritime pine, PEA, and fatty acids from hemp seed oil) while deliberately excluding phytocannabinoids from the composition, thereby maintaining nutraceutical eligibility while preserving therapeutic efficacy
Solution Approach 2:
The invention uses procyanidins and fatty acids as intermediary substances that can deliver anti-inflammatory effects similar to phytocannabinoids but without the regulatory restrictions, allowing the composition to function as both a pharmaceutical and nutraceutical product
3Device complexity
If single substance treatments are used, then treatment simplicity is maintained, but efficacy is limited
Solution Approach 1:
The patent merges multiple active compounds with complementary mechanisms of action (PEA for analgesia, procyanidins for anti-inflammatory effect, and fatty acids for membrane stabilization) into a single integrated formulation, achieving synergistic efficacy while maintaining treatment simplicity through a unified product
Data Source
Figure 1A~1D
Figure 2~3A
Figure 3B~3C
AI summary
Pharmaceutical or nutraceutical composition comprising palmitoylethanolamide (PEA), dry extract of maritime pine and hemp seed oil substantially free from phytocannabinoids, for use in the treatment of pelvic pain, preferably the composition comprising from 100 to 1200 mg of PEA, from 2.5 to 30 mg of dry extract of maritime pine in quantities of 1.6 to 4.2 mg, and from 12.5 to 150 mg of hemp seed oil substantially free from phytocannabinoids.