Pencil-like Optical Fiber Sensor Probe for Portable Immunosensing
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Solution Overview
Problem
Current chemiluminescent optical fiber immunosensors for disease marker detection are complex, costly, and not portable, limiting their use in point-of-care testing due to the need for liquid control systems and charge coupled devices, which complicates miniaturization and integration.
Innovation Solution
A pencil-like optical fiber sensor probe with a compact, reusable design incorporating an inner tube, casing, clamping device, and optical probe, combined with a portable immunosensor featuring an immersion immune response reagent strip and a battery-powered photon counting detector, allowing for simplified and sensitive detection of inflammatory markers like interleukin-6, procalcitonin, and C-reactive protein.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional chemiluminescent optical fiber immunosensors are used, then detection sensitivity is improved, but device complexity and cost increase due to liquid control systems and charge coupled devices
Solution Approach 1:
The patent extracts and eliminates the complex liquid control systems and charge coupled devices from the traditional chemiluminescent immunosensor system. By using a pencil-like optical fiber sensor probe that directly converts immune recognition into luminescent signals, the system removes unnecessary components while maintaining detection sensitivity, thereby simplifying the overall structure and reducing cost.
Solution Approach 2:
The optical fiber sensor probe serves multiple functions: it acts as both the sensing element and the signal transmission medium. The probe integrates the chemiluminescent reaction site with the light guide function, eliminating the need for separate liquid control systems and detection devices, thus achieving multi-functionality with a single component.
2Measurement precision
If traditional chemiluminescent optical fiber immunosensors are used, then detection sensitivity is improved, but miniaturization and portability are limited
Solution Approach 1:
The patent segments the immunosensor system into a compact pencil-like optical fiber sensor probe that can be easily miniaturized. By dividing the system into a small probe unit with integrated sensing and signal transmission capabilities, the design enables portability while maintaining the detection sensitivity required for accurate biomarker analysis.
3Measurement precision
If clinical analysis methods are used, then detection accuracy is improved, but operational complexity and professional requirements increase
Solution Approach 1:
The pencil-like optical fiber sensor probe is designed for self-service operation in point-of-care testing. The probe directly converts immune recognition into luminescent signals without requiring complex liquid control systems or professional operational procedures. Users can simply insert the probe into the sample, and the system automatically performs detection, maintaining clinical-grade accuracy while eliminating the need for specialized training.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system reduces experimental costs, enables easy operation, and provides high stability and sensitivity for point-of-care testing, with each optical probe capable of up to 10 immunoassays and maintaining 90% response stability after 14 days of storage, suitable for in-situ analysis.
Implementation Method 1
an optical fiber and an optical probe; wherein the optical fiber and the optical probe are coaxially connected in the clamping device, so that light is guided from the optical probe to the optical fiber to the maximum
Implementation Method 2
The chemiluminescent optical fiber immunosensor directly converts immune recognition into luminescent signals
Data Source
AI summary
The present invention discloses a pencil-like optical fiber sensor probe, including an inner tube, a light screening casing, a clamping device, an optical fiber and an optical probe; a portable immunosensor, including the pencil-like optical fiber sensor probe, an immersion immune response reagent strip, a touch-screen computer, a compact battery-powered sensitive photon counting detector and a case; and a use of the immunosens in detecting inflammatory markers. The design of the pencil-like optical sensor probe greatly simplifies the immune analysis process by combining the immersion immune response reagent strip. Each optical probe allows for up to 10 immunoassays, which reduces the experimental cost and avoids frequent replacement of the probe. The integrated detecting system is powered by battery which is suitable for in-situ analysis and detection. The sensor also has a high stability and sensitivity.