Pentosan Polysulfate Therapy for Psoriasis With Fewer Side Effects
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Solution Overview
Problem
Current treatments for psoriasis, psoriatic arthritis, and dermatitis focus on symptom management with frequent administration and often have serious side effects, lacking a cure for these chronic conditions.
Innovation Solution
Administering pentosan polysulfate or its pharmaceutically acceptable salts through various routes to treat psoriasis, psoriatic arthritis, and dermatitis, utilizing formulations such as creams, ointments, and injectable compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments (corticosteroids, immunosuppressives, biologics) are used to manage psoriasis, dermatitis and psoriatic arthritis symptoms, then symptom control is achieved, but serious side effects occur and frequent prolonged administration is required
Solution Approach 1:
The patent changes the chemical parameter by substituting conventional treatment agents (corticosteroids, immunosuppressives) with pentosan polysulfate, a different chemical entity that achieves therapeutic effect through a different mechanism, thereby reducing harmful side effects while maintaining symptom control
Solution Approach 2:
The patent extracts and isolates the beneficial therapeutic effect from the harmful side effects by using pentosan polysulfate, which provides anti-inflammatory and immunomodulatory benefits without the severe side effects associated with conventional treatments
2Reliability
If current treatments are administered frequently over prolonged periods to manage chronic conditions, then symptom management is maintained, but treatment complexity and patient burden increase
Solution Approach 1:
The patent changes the temporal parameter of treatment by demonstrating that pentosan polysulfate achieves sustained therapeutic effects with less frequent administration compared to conventional treatments, reducing patient burden while maintaining symptom management
3Reliability
If no curative treatment exists for psoriasis, dermatitis and psoriatic arthritis, then only symptom management is possible, but long-term symptom control requires continuous treatment
Solution Approach 1:
The patent applies preliminary action by using pentosan polysulfate to potentially modify the underlying disease process and immune dysregulation, which may lead to longer-lasting remission periods and reduced need for continuous treatment compared to conventional symptomatic management
Data Source
AI summary
The disclosure of the present invention relates to methods, uses and compositions for the treatment of psoriasis, psoriatic arthritis and dermatitis with pentosan polysulfate, or a pharmaceutically acceptable salt thereof.