Peony Stamen-Dodder Composite for CKD Treatment
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Solution Overview
Problem
Current treatments for chronic kidney disease (CKD) are limited in efficacy and often accompanied by significant side effects, failing to adequately address the underlying pathogenesis and symptoms such as frequent urination and nocturia.
Innovation Solution
A peony stamen-dodder composite is developed, comprising 10-18 parts by weight of peony stamen and 5-12 parts by weight of dodder, processed through desensitization, impregnation, and ultrasonic treatment to create a therapeutic agent that is administered to target the kidney meridian.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional drug therapy (thiazide diuretics, ACEI, glucocorticosteroids, cytotoxic drugs, antiplatelet drugs) is used to treat chronic kidney disease, then symptoms such as edema, hematuria, and proteinuria can be improved, but the treatment is accompanied by obvious side effects and limited efficacy for patients with poor renal function
Solution Approach 1:
The patent uses traditional Chinese medicine compounds (peony stamen and dodder) as intermediary substances to treat chronic kidney disease. These natural medicines act as mediators that can improve renal function and reduce symptoms without producing the severe side effects associated with conventional Western medications. The peony stamen contains paeoniflorin and flavonoids, while dodder provides nourishing effects, creating a synergistic therapeutic approach that bridges conventional and traditional medicine systems.
Solution Approach 2:
The patent changes the therapeutic parameters by using natural medicine compounds with different chemical compositions and mechanisms of action compared to conventional drugs. The peony stamen-dodder composite contains various active ingredients including paeoniflorin, flavonoids, and other phytochemicals that can modulate renal function through multiple pathways, providing a broader therapeutic window and reduced toxicity profile.
2Reliability
If ACEI is used to treat chronic kidney disease, then proteinuria and blood pressure can be controlled, but persistent dry cough and other side effects occur in some patients
Solution Approach 1:
The patent employs natural medicine compounds that can be administered repeatedly without accumulating toxic effects. The peony stamen and dodder provide a renewable, natural source of therapeutic agents that can be used long-term without the cumulative side effects of ACEI, offering a sustainable alternative for chronic kidney disease management.
3Reliability
If glucocorticoids and cytotoxic drugs are actively applied to treat chronic kidney disease, then inflammatory responses can be suppressed, but the treatment produces side effects such as abdominal distension, cough, tonsillar redness and pain, and dry and sore throat
Solution Approach 1:
The patent creates a composite medicinal preparation combining peony stamen and dodder. This composite approach integrates the anti-inflammatory properties of peony stamen (containing paeoniflorin and flavonoids) with the nourishing and kidney-protective effects of dodder, creating a synergistic formulation that suppresses inflammation while minimizing side effects through the complementary actions of multiple natural compounds.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peony stamen-dodder composite demonstrates significant therapeutic effects on CKD by reducing urinary albumin excretion, lowering uric acid, blood urea nitrogen, and creatinine levels, and alleviating pathological changes in the kidney, as evidenced by rat model studies.
Implementation Method 1
The peony stamen is subjected to desensitization, impregnation with a first saline for 10 min and drying
Implementation Method 2
impregnation with a first saline for 10 min and drying, and subjecting the dodder to impregnation with a second saline for 20 min and baking
Implementation Method 3
crushing a treated peony stamen obtained in step (1), and crushing a treated dodder obtained in step (1); impregnating a crushed peony stamen and a crushed dodder with warm water followed by a first ultrasonic treatment and filtration
Data Source
AI summary
A peony stamen-dodder composite, which is prepared from 10-18 parts by weight of peony stamen and 5-12 parts by weight of dodder. In the preparation process, the peony stamen is sequentially subjected to desensitization, impregnation with a saline and drying, and the dodder is impregnated with a saline and baked. The pre-treated peony stamen and dodder are crushed, impregnated in warm water, ultrasonicated and filtered, and the filter residue is added with water, ultrasonicated and filtered. The filtrates are combined and concentrated under vacuum to obtain the desired composite. This application further provides an application of the composite in the treatment of nephritis.