Peppermint Extract for NOTCH Protein Expression in Mature Skin
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Solution Overview
Problem
Current cosmetic compositions do not effectively address the renewal of epidermal cells, particularly in mature and dry skin, due to deficiencies in NOTCH protein expression in progenitor keratinocytes, which are crucial for skin regeneration and barrier function.
Innovation Solution
Incorporating peppermint extract (Mentha piperita) in cosmetic compositions to stimulate the expression of NOTCH proteins in keratinocytes, using enzymatic hydrolysis of aerial plant parts in an aqueous medium, which enhances cellular renewal and regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional cosmetic compositions are used, then general skin care functions are provided, but they fail to effectively address epidermal cell renewal in mature and dry skin
Solution Approach 1:
Peppermint extract serves as an intermediary substance that mediates between the external cosmetic application and the internal NOTCH signaling pathway in keratinocytes. The extract contains bioactive compounds that penetrate the skin and activate NOTCH receptors, thereby stimulating epidermal cell renewal without directly modifying the genetic material or cellular structure
Solution Approach 2:
The invention changes the biochemical parameter of NOTCH protein expression levels in keratinocytes by applying peppermint extract. This external agent modifies the expression level parameter of NOTCH proteins, thereby enhancing the renewal rate of epidermal cells in mature and dry skin conditions
2Productivity
If peppermint extract is applied to stimulate NOTCH protein expression, then epidermal cell renewal is enhanced, but the complexity of the cosmetic composition increases
Solution Approach 1:
The invention extracts and utilizes only the essential bioactive components from peppermint that are responsible for stimulating NOTCH protein expression. This extraction approach allows the cosmetic composition to achieve the desired skin regeneration effect while maintaining formulation simplicity by focusing on key active ingredients rather than using the entire plant material
Solution Approach 2:
Peppermint extract serves multiple functions simultaneously: it acts as a NOTCH pathway activator, provides antioxidant protection, and offers anti-inflammatory benefits. This multi-functionality allows a single ingredient to address multiple skin concerns, thereby enhancing skin regeneration without proportionally increasing formulation complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peppermint extract significantly stimulates NOTCH protein expression, promoting the renewal of epidermal cells, improving skin regeneration and barrier function, particularly in mature and dry skin, thereby addressing deficiencies in NOTCH protein expression.
Implementation Method 1
using enzymatic hydrolysis of aerial plant parts in an aqueous medium
Data Source
Figure 1~2
AI summary
The present invention relates to the use, in a cosmetic composition, of a peppermint extract as an agent for increasing renewal of skin cells that is associated with deficiency in NOTCH protein expression in the keratinocyte progenitor cells, said agent being particularly for mature skin or skin having signs of dryness or loss of firmness. The invention also relates to a cosmetic care method for maintaining or controlling renewal of skin cells that is associated with deficiency in NOTCH protein expression in the keratinocyte progenitor cells, said cosmetic care method being intended for mature and/or dry skin.