Peptide-Conjugated Resin Coating for Thick Cell Scaffolds

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Solution Overview

Problem

The preparation of cell scaffolds with large thickness using synthetic resin bonded with peptides is complicated, making it difficult to enhance cell proliferation effectively.

Innovation Solution

A coating solution containing peptide-conjugated resin with a synthetic resin moiety and a peptide moiety, along with an alcohol solvent, is developed, which includes a peptide content of 0.1 wt% or more, allowing for easy formation of thick cell scaffolds and enhanced cell proliferation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If a solid phase method is used to prepare cell scaffolds with large thickness, then cell proliferation can be enhanced, but the preparation process becomes complicated

Engineering Contradiction:

Improvecell proliferationVSAvoidpreparation process complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The invention changes the preparation method from solid phase to solution phase, and specifies particular parameters for the coating solution including peptide-conjugated resin content (0.1-10 wt%), alcohol solvent type, and pH range (5-7). These parameter changes enable simple preparation of thick cell scaffolds while maintaining enhanced cell proliferation

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention replaces the mechanical solid phase preparation method with a chemical solution phase method. By using peptide-conjugated resin in alcohol solvent that can be applied via coating, the complex mechanical assembly process is substituted with a simple chemical solution application process, achieving both simplicity and effectiveness

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Productivity

If natural polymer materials are used for cell scaffolds, then cell proliferation is enhanced, but cost increases and lot variation occurs

Engineering Contradiction:

Improvecell proliferationVSAvoidmanufacturing consistency and cost

Core Design Contradiction:

ProductivityVSEase of manufacture

Solution Approach 1:

The invention creates a composite material system combining synthetic resin (polyvinyl alcohol derivative or (meth)acrylic copolymer) with peptide moieties. This composite approach maintains the biological activity of peptides while using inexpensive, consistent synthetic polymer backbones, eliminating lot variation and reducing cost compared to natural polymers alone

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The invention uses inexpensive synthetic resin materials that can be readily discarded after use, replacing expensive natural polymer materials. The peptide-conjugated synthetic resin provides sufficient functionality for cell proliferation without the high cost and variability of natural polymers, enabling cost-effective single-use cell scaffolds

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Data Source

PatentUS20250011475A1Coating solution for forming cell scaffold and production method thereof

Publication Date: 2025.01.09 SEKISUI CHEMICAL CO LTD

AI summary

Provided is a coating solution for forming a cell scaffold with which a cell scaffold having a large thickness can be easily formed and the proliferation of cells can be enhanced. A coating solution for forming a cell scaffold according to the present invention contains a peptide-conjugated resin having a synthetic resin moiety and a peptide moiety and an alcohol solvent, a content of the peptide-conjugated resin being 0.1 wt % or more.