Peptide Core Linker for Modular Molecular Constructs
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Solution Overview
Problem
Current methods for constructing molecular constructs with specific combinations of targeting and effector elements are challenging due to difficulties in linking different functional elements using chemical synthesis or recombinant technology, limiting the versatility of molecular platforms for various disease applications.
Innovation Solution
A peptide core-based multi-arm linker unit with a polypeptide core and linking arms, allowing for the linkage of different functional elements via various chemical reactions such as amide bonding, thiol-maleimide reactions, and click chemistry, enabling the facile synthesis of molecular constructs with complex structures and adjustable functional elements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If chemical synthesis or recombinant technology is used to link different functional elements, then molecular constructs can be formed, but the construction process becomes challenging and versatility is limited
Solution Approach 1:
The invention divides the molecular construct into separate functional elements (targeting element and effector element) that can be independently synthesized and then linked together through a linker, enabling modular assembly and improved versatility
Solution Approach 2:
The linker is designed with universal functionality to connect different types of functional elements through various chemical reactions (amide bonding, thiol-maleimide reactions, click chemistry), making the molecular platform adaptable to multiple therapeutic applications
2Reliability
If complex molecular constructs with multiple functional elements are synthesized, then therapeutic efficacy is enhanced, but the synthesis process becomes more difficult
Solution Approach 1:
The functional elements and linker are prepared separately before final assembly, allowing each component to be optimized and purified independently, which simplifies the overall synthesis process while ensuring high therapeutic efficacy
Solution Approach 2:
The linker serves as an intermediary component that facilitates the connection between targeting and effector elements through well-established chemical reactions, making the synthesis of complex constructs more manageable and reliable
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the construction of molecular constructs with precise control over the number and type of functional elements, facilitating the generation of libraries and specific combinations for targeted therapeutic applications, enhancing therapeutic efficacy and reducing side effects.
Implementation Method 1
linkage of different functional elements via various chemical reactions such as amide bonding
Implementation Method 2
linkage of different functional elements via various chemical reactions such as thiol-maleimide reactions
Implementation Method 3
linkage of different functional elements via various chemical reactions such as click chemistry
Data Source
Figure 1A~1C
Figure 1D~1F
Figure 1G~1I
AI summary
The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.