Peptide Signaling for Dentin, Bone, and Cementum Regeneration
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Solution Overview
Problem
Current treatments for dental pulp and periodontal diseases, such as dental pulp necrosis and periodontal tissue loss, are inadequate in promoting effective regeneration of hard tissues like dentin, bone, and cementum, and often result in re-infection and aesthetic issues.
Innovation Solution
A novel peptide with a specific amino acid sequence, potentially modified, is used to promote the regeneration of hard tissues and treat dental pulp and periodontal diseases by increasing the expression of marker genes for odontoblast, osteoblast, and cementoblast differentiation, and is administered with human dental pulp cells to form dentin/pulp-like and bone-like tissues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If MTA is used for treatment, then sealing force and biocompatibility are improved, but cost increases and aesthetic problems occur due to discoloration
Solution Approach 1:
The patent uses a biodegradable polymer (poly(lactide-co-glycolide) or poly(D,L-lactide)) that serves as a temporary scaffold for tissue regeneration. This scaffold degrades over time as new tissue forms, eliminating the need for permanent implants and avoiding long-term aesthetic issues while maintaining sealing and biocompatibility during the critical healing period.
Solution Approach 2:
The patent changes the material parameters by using biodegradable polymers with controlled degradation rates. The scaffold's mechanical properties and composition are optimized to provide initial structural support and sealing, then gradually degrade as regenerated tissue takes over, thus avoiding permanent discoloration while maintaining reliability during treatment.
2Ease of manufacture
If conservative treatment methods are used, then cost is reduced, but the treated tooth becomes weak and brittle with risk of re-infection
Solution Approach 1:
The patent applies a peptide composition before the tooth structure fully degrades, promoting regeneration of dentin and dental pulp tissue in advance. This preliminary regenerative action strengthens the tooth structure before conservative treatment completes, preventing weakness and brittleness while maintaining cost-effectiveness.
Solution Approach 2:
The patent uses a composite approach combining biodegradable polymer scaffolds with peptide compositions (such as RGD peptide or BMP-2 peptide) to create a material system that simultaneously provides structural support, promotes tissue regeneration, and maintains tooth strength. This composite material strategy avoids the weakness associated with simple conservative treatments.
3Object-affected harmful factors
If dental pulp is removed, then infection is eliminated, but dental pulp vitality is lost resulting in unphysiological treatment
Solution Approach 1:
The patent converts the harmful presence of infected pulp into a beneficial regenerative stimulus. By applying peptide compositions (such as BMP-2 or RGD peptides) to the affected area, the treatment transforms the pathological state into an opportunity for controlled regeneration of healthy dental pulp tissue, eliminating infection while preserving vitality.
Solution Approach 2:
The patent introduces a peptide composition as an intermediary substance that mediates between the infected pulp and the desired healthy regenerated tissue. The peptide acts as a signaling molecule that guides stem cells to differentiate into odontoblasts and regenerate functional pulp tissue, thus eliminating infection pathways while restoring vitality through controlled biological mediation.
4Reliability
If periodontal ligament fibroblasts are utilized, then restoration and regeneration of alveolar bone and cementum are improved, but treatment complexity increases
Solution Approach 1:
The patent extracts and isolates periodontal ligament fibroblasts from the complex periodontal tissue environment, then applies them in a controlled manner using peptide-enhanced delivery systems. This extraction approach maintains the regenerative capability of these specialized cells while simplifying the overall treatment protocol by separating the key regenerative element from the complex tissue source.
Data Source
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AI summary
The present invention relates to a novel peptide, a polynucleotide encoding the peptide, an expression vector including the polynucleotide, and a pharmaceutical composition, quasi-drug composition, and health functional food composition including the peptide.