Peptide-Crosslinked Hyaluronic Acid Hydrogel With Tunable Elasticity
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Solution Overview
Problem
Conventional hyaluronic acid cross-linking methods using BDDE cross-linking agents result in adverse reactions and side effects, and the process is inefficient, requiring extensive purification and time, while also limiting the control over physical properties of the resulting filler.
Innovation Solution
A hyaluronic acid-based hydrogel is created through cross-linking hyaluronic acid with a peptide cross-linking agent, forming an amide bond between the carboxylic acid group of hyaluronic acid and the amine group of the peptide, which reduces side effects and allows for better control over physical properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If BDDE cross-linking agent is used to cross-link hyaluronic acid, then the decomposition period and physical properties are improved, but adverse reactions and side effects occur due to residual cross-linking agent
Solution Approach 1:
The patent changes the chemical nature of the cross-linking agent from BDDE (epoxide group) to a peptide-based cross-linking agent with amine groups. This parameter change in chemical composition allows for biocompatible cross-linking that does not produce harmful residues, resolving the contradiction between extended duration and harmful effects.
Solution Approach 2:
The peptide cross-linking agent is designed to be fully biodegradable and metabolizable, effectively acting as a temporary tool that completes its cross-linking function and then is safely eliminated by the body, eliminating the problem of persistent harmful residues while maintaining the desired duration of action.
2Strength
If BDDE cross-linking agent is used, then cross-linking binding is achieved, but extensive purification time and cost are incurred to remove residual cross-linking agent
Solution Approach 1:
The peptide cross-linking agent performs self-purification through natural metabolic processes. After completing its cross-linking function, the peptide is naturally degraded and eliminated by bodily enzymes, eliminating the need for extensive external purification processes while maintaining strong cross-linking bonds.
3Reliability
If peptide cross-linking agent is used, then safety and elasticity are improved, but new cross-linking methodology is required
Solution Approach 1:
The patent substitutes the chemical mechanism of BDDE cross-linking (epoxide-alcohol reaction) with a peptide-based amine-carboxyl cross-linking mechanism. This substitution maintains the essential cross-linking function while improving safety through biocompatibility, and the increased process complexity is offset by the elimination of purification steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peptide cross-linked hyaluronic acid hydrogel exhibits higher elasticity and stability, minimizing adverse reactions and enabling tailored physical properties, making it suitable for various cosmetic and therapeutic applications.
Implementation Method 1
a carboxylic acid group of hyaluronic acid and an amine group of the peptide cross-linking agent are reacted to form an amide bond
Data Source
AI summary
The present invention relates to a hyaluronic acid-based hydrogel which is a hyaluronic acid-peptide crosslinked body crosslinked using a peptide crosslinking agent. More specifically, the present invention relates to a hyaluronic acid-based hydrogel and a method for producing same, wherein a crosslinked body having novel physical properties is obtained using a relatively small amount of a crosslinking agent that forms peptide bonds, unlike conventional crosslinking agents, and the hyaluronic acid-based hydrogel has the advantages of: being safe and having few side effects; the physical properties of a filler being adjustable according to the amount of peptide crosslinking; and having a high elasticity ratio.