Self-Assembling Peptide Hydrogel for GI Obstruction Prevention
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Solution Overview
Problem
Current treatments for gastric ESD-induced ulcers often result in gastrointestinal obstruction due to stenosis, a narrowing of the gastrointestinal tract that can lead to partial or full obstruction, with no effective prevention methods available, leading to significant quality of life drops and the need for repeated treatments like balloon dilatation and steroid injections.
Innovation Solution
A composition comprising a self-assembling peptide, specifically (RADA)4, is administered as a hydrogel to the affected area, forming under physiological conditions to prevent or reduce stenosis by promoting healing and reducing scar contraction, which is delivered via a catheter for targeted application and can be used with or without biologically active agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If endoscopic submucosal dissection (ESD) is performed to remove lesions, then complete resection is achieved, but gastrointestinal obstruction due to stenosis occurs
Solution Approach 1:
The hydrogel is applied to the resection site immediately after ESD procedure, before stenosis develops. This preliminary action prevents scar contraction and maintains lumen patency during the healing process, thereby preventing gastrointestinal obstruction while preserving the complete resection benefit
2Duration of action of moving object
If traditional treatments are used for ESD-induced ulcers, then ulcer healing is attempted, but stenosis develops causing obstruction
Solution Approach 1:
The hydrogel acts as an intermediary substance applied to the ulcer bed during healing. It modifies the healing process by preventing excessive scar contraction while allowing ulcer healing to proceed, thereby eliminating stenosis as a harmful factor without compromising ulcer healing
3Ease of operation
If balloon dilatation and steroid injections are used to treat stenosis, then obstruction is temporarily relieved, but repeated treatments are required
Solution Approach 1:
By applying the hydrogel immediately after ESD, the invention prevents stenosis formation in the first place, eliminating the need for repeated balloon dilatation and steroid injections. This preliminary preventive action saves time by avoiding multiple follow-up treatments
Solution Approach 2:
The hydrogel performs preliminary anti-action by preventing scar contraction before it can cause stenosis. This preemptive approach counteracts the pathological process before it leads to obstruction, eliminating the need for subsequent corrective treatments
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The self-assembling peptide hydrogel effectively reduces the risk of post-ESD bleeding, promotes healing, and prevents stenosis, allowing the gastrointestinal tract to return to a pre-operative state, thereby alleviating obstruction and improving patient recovery without adverse effects.
Implementation Method 1
a self-assembling peptide, the peptide in the solution consisting essentially of (RADA)4
Implementation Method 2
the peptide in the solution... to form a hydrogel under physiological conditions
Data Source
Figure 1A~1C
Figure 1D~1F
Figure 2A~2C
AI summary
Materials and methods for preventing gastrointestinal obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. The peptide may undergo self-organization under physiological conditions and/or in the presence of a cation.