Self-Assembling Peptide Hydrogel for Tissue Occlusion and Hemostasis
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Solution Overview
Problem
Existing hemostatic agents for tissue damage, such as collagen fibers and fibrin paste, pose risks of infection and are less effective during heparinemia, while other methods cause thermal injury or require expert skill, and there is a need for effective occlusion of body fluid leakage in various clinical scenarios.
Innovation Solution
A self-assembling peptide hydrogel, formed by an aqueous solution of specific amino acid sequences, is applied to tissue damage sites after excess body fluid removal, providing a scaffold for cell adhesion and occlusion, optionally with added small molecular drugs for enhanced efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If collagen fibers or fibrin paste are used for hemostasis, then hemostatic effect is improved, but risk of infection increases and transparency is lost
Solution Approach 1:
The patent changes the fundamental parameter of material origin from animal-derived (collagen, fibrin) to synthetic peptide. The peptide is designed with specific amino acid sequences that enable self-assembly into gel structures, providing hemostatic functionality without animal-derived components, thereby eliminating infection risk while maintaining effectiveness
Solution Approach 2:
The invention creates a composite functional material that combines synthetic peptide with self-assembling gel properties. The peptide forms a three-dimensional gel network structure that mimics natural extracellular matrix, providing both hemostatic function and biocompatibility without the drawbacks of traditional animal-derived materials
2Reliability
If collagen fibers or fibrin paste are used for hemostasis, then hemostatic effect is improved, but transparency is lost interfering with surgery
Solution Approach 1:
The patent changes the optical parameter of transparency by using synthetic peptide with controlled molecular weight and amino acid composition. The self-assembled gel structure of the peptide maintains optical clarity, allowing surgeons to visualize the surgical field while the hemostatic agent is in place, unlike opaque animal-derived materials
3Reliability
If electrocautery is used for hemostasis, then hemorrhage arrest is improved, but thermal injury to surrounding tissue occurs
Solution Approach 1:
The patent replaces the thermal/electrical mechanism of electrocautery with a mechanical/physical mechanism. The synthetic peptide gel physically occludes blood vessels and seals tissue through its gel structure and adhesion properties, eliminating thermal injury to surrounding tissues while achieving effective hemorrhage arrest
4Reliability
If direct compression is used for hemostasis, then hemorrhage control is improved, but time and effort are required and hematoma risk increases
Solution Approach 1:
The patent applies a self-service principle where the synthetic peptide gel automatically adheres to the tissue surface and forms a stable occlusive layer without requiring continuous external compression or maintenance. The gel's adhesion properties and structural stability enable it to maintain hemorrhage control independently, reducing time and effort requirements while minimizing hematoma formation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The self-assembling peptide hydrogel achieves effective tissue occlusion with biological safety, adhering well to tissue and maintaining hemostasis, even in conditions of reduced clotting or complex hemorrhage, and is biodegradable without infection risk.
Implementation Method 1
a self-assembling peptide hydrogel, formed by an aqueous solution of specific amino acid sequences, is applied to tissue damage sites
Implementation Method 2
The self-assembling peptide hydrogel achieves effective tissue occlusion with biological safety, adhering well to tissue
Data Source
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AI summary
There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like. The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.