Skin-Improving Peptide Sequence for Penetration and Stability
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Solution Overview
Problem
Existing peptides for skin improvement face challenges such as poor tissue penetration and short half-life, limiting their effectiveness in promoting collagen synthesis and enhancing skin barrier function.
Innovation Solution
A peptide with a specific amino acid sequence (SEQ ID NO: 1) is synthesized, which can be chemically modified for stability and specificity, and formulated into cosmetic and pharmaceutical compositions to enhance skin penetration and promote fibroblast proliferation, collagen synthesis, and skin barrier factors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing peptides are used for skin improvement, then collagen synthesis promotion and fibroblast proliferation are achieved, but tissue penetration is poor and half-life is short
Solution Approach 1:
The patent modifies the amino acid sequence parameters of the peptide to create a novel sequence (SEQ ID NO: 1) that achieves both effective collagen synthesis promotion and extended half-life. The specific parameter changes in the peptide structure enable improved tissue penetration and stability while maintaining biological activity.
Solution Approach 2:
The patent combines the peptide with specific carriers or delivery systems to create a composite formulation that enhances tissue penetration and extends the peptide's half-life. This composite approach allows the peptide to maintain its collagen-synthesis-promoting activity while overcoming its inherent limitations of poor penetration and short duration.
2Duration of action of moving object
If peptide structure is modified for stability, then half-life is extended, but tissue penetration may be reduced
Solution Approach 1:
The patent carefully balances the amino acid sequence parameters to achieve optimal half-life extension without compromising tissue penetration. The specific modifications in SEQ ID NO: 1 are designed to enhance stability while preserving the peptide's ability to penetrate skin tissue effectively.
Solution Approach 2:
The patent introduces carrier molecules or delivery vehicles as intermediaries that facilitate tissue penetration of the modified peptide. These intermediaries protect the peptide structure during delivery while enabling effective penetration into target tissues, thus resolving the contradiction between stability modifications and penetration capability.
3Productivity
If existing peptides are applied to skin, then some collagen synthesis is promoted, but skin barrier function enhancement is insufficient
Solution Approach 1:
The patent designs the peptide with multi-functional capabilities, where SEQ ID NO: 1 simultaneously promotes collagen synthesis and enhances skin barrier function. This universal peptide structure addresses multiple skin improvement needs in a single formulation, rather than requiring separate treatments for each function.
Solution Approach 2:
The patent creates a composite formulation that includes the peptide along with additional components that work synergistically to enhance both collagen synthesis and skin barrier function. The composite nature of the formulation allows simultaneous achievement of multiple skin improvement goals that single-component peptides cannot achieve alone.
Data Source
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Figure 3A~3C
AI summary
The present application relates to a peptide having the activity of improving the state of skin and uses thereof, and provides a peptide consisting of an amino acid sequence of SEQ ID NO: 1 and a cosmetic composition for improving the state of skin, including, as an active ingredient, the peptide consisting of the amino acid sequence of SEQ ID NO: 1.