Peptide Composition Stabilized for Long-Term Solubility
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Solution Overview
Problem
Existing peptide formulations struggle with long-term stability and solubility issues due to differences in amino acid sequences, making it difficult to maintain effective concentrations and stability of multiple types of peptides in a single preparation.
Innovation Solution
A composition comprising peptides stabilized by a combination of saccharides, such as sucrose, and inorganic salts, particularly sodium chloride, with controlled pH and oxygen levels, ensuring long-term stability and solubility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If multiple types of peptides are included in the same preparation to increase vaccine effect, then the vaccine effectiveness increases, but the solubility and stability of the peptides deteriorate due to increased peptide concentration and interaction between different peptide types
Solution Approach 1:
The patent introduces specific stabilizing agents (sucrose, trehalose, glycerol, or a combination thereof) as intermediary substances that mediate between the peptides and the formulation environment. These stabilizing agents interact with the peptides to maintain their structural integrity and prevent aggregation, thereby enabling the stable coexistence of multiple peptide types in a single formulation while preserving vaccine effectiveness.
2Productivity
If multiple types of peptides are included in the same preparation to increase vaccine effect, then the vaccine effectiveness increases, but the solubility of the peptides deteriorates due to increased peptide concentration per unit volume
Solution Approach 1:
The stabilizing agents (sucrose, trehalose, glycerol) serve as intermediary substances that facilitate the dissolution and distribution of multiple peptide types in the formulation. They interact with the peptide molecules to maintain solubility even at high concentrations, preventing precipitation and aggregation issues that would otherwise occur when combining multiple peptide types in a single preparation.
3Adaptability or versatility
If different amino acid sequences of peptides are used to create diverse vaccine targets, then the vaccine coverage increases, but the stability of the peptide formulation becomes unpredictable due to varying peptide characteristics
Solution Approach 1:
The patent employs stabilizing agents (sucrose, trehalose, glycerol) that provide universal stabilization across different peptide sequences regardless of their specific amino acid composition. These stabilizing agents interact generally with peptide structures to maintain stability, making the formulation approachable and predictable for diverse peptide vaccines targeting different cancer antigens without requiring sequence-specific stabilization strategies.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides stable and soluble peptide formulations that can be preserved for extended periods, maintaining peptide integrity and reducing impurities, thereby enhancing the effectiveness of peptide-based treatments.
Implementation Method 1
A composition comprising peptides stabilized by containing a saccharide and an inorganic salt, especially sucrose and sodium chloride
Implementation Method 2
which can be dissolved in water
Data Source
AI summary
Provided herein is a peptide composition that is highly stable and can be stored long term, said composition containing one or more types of peptides having an amino acid sequence represented by any of SEQ ID Nos. 1-5, or a peptide in which one or two of the amino acids of the abovementioned peptides are independent and may be substituted, deleted or added, and saccharides and an inorganic salt.