Peptide Composition Modulating Synaptic Plasticity for Cognitive Dysfunction
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Solution Overview
Problem
Current treatments for cognitive dysfunction, such as Alzheimer's disease, fail to effectively address synaptic degeneration and plasticity abnormalities, leading to impaired learning and memory.
Innovation Solution
A pharmaceutical or food composition containing a peptide with a specific amino acid sequence (SEQ ID NO: 1) that directly binds to the CCNY protein, inducing long-term potentiation in synapses and improving synaptic plasticity, thereby alleviating cognitive dysfunction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for cognitive dysfunction are used, then general cognitive symptoms are addressed, but synaptic degeneration and plasticity abnormalities are not effectively treated
Solution Approach 1:
The patent changes the chemical parameter by introducing a specific peptide sequence (SEQ ID NO: 1) with unique amino acid composition that targets synaptic plasticity mechanisms, transforming the treatment approach from general cognitive support to specific synaptic regulation
Solution Approach 2:
The peptide acts as a biological intermediary that mediates between existing neurotransmitter systems and synaptic plasticity outcomes, facilitating communication and coordination between different neural signaling pathways to enhance learning and memory
2Reliability
If synaptic plasticity is enhanced through the peptide, then long-term potentiation increases, but the complexity of the treatment mechanism increases
Solution Approach 1:
The patent extracts and isolates the specific peptide sequence (SEQ ID NO: 1) from complex biological systems, identifying its unique ability to enhance LTP and synaptic plasticity, thereby simplifying the treatment mechanism to a targeted molecular intervention rather than broad physiological modulation
3Ease of operation
If the peptide binds to CCNY protein to induce LTP, then cognitive function improves, but the specificity of the target protein reduces treatment versatility
Solution Approach 1:
The peptide exhibits multi-functionality by binding to CCNY protein to induce LTP while also potentially addressing various forms of cognitive dysfunction and neurodegenerative conditions, making it applicable across multiple disease states and cognitive impairments
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peptide composition effectively increases long-term potentiation in hippocampal tissue, improving cognitive function and potentially treating various neurodegenerative diseases associated with cognitive decline.
Implementation Method 1
A pharmaceutical or food composition containing a peptide with a specific amino acid sequence (SEQ ID NO: 1) that directly binds to the CCNY protein
Data Source
AI summary
A method of preventing, ameliorating, or treating a cognitive dysfunction in a subject in need thereof, includes administering a pharmaceutical composition including a peptide represented by the amino acid sequence of SEQ ID NO: 1 as an active ingredient. Any one or more of the N-and C-termini of the peptide are modified and the modification is acetylation or amidation.