Peptide Trigger Factor Complexes for Skin Regeneration
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Solution Overview
Problem
Conventional cosmetic interventions for skin regeneration often rely on 'one-entity-one-target' strategies, which have limited efficacy and can lead to persistent reliance on short-term modulation, failing to overcome regulatory deadlocks in skin homeostasis and wound healing, especially in cases of large wounds, aging, or chronic insults.
Innovation Solution
The development of novel peptide or peptide-derived agents, including those that stimulate the Wnt/β-catenin signaling pathway, agonists/antagonists of the EPOR/CD131 receptor, and variants of human TGF-β3, which form trigger factor complexes for synergistic action, enhancing skin regeneration and stability in cosmetic formulations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cosmetic interventions use one-entity-one-target strategies, then the formulation is simple, but the efficacy is limited and cannot overcome regulatory deadlocks in skin homeostasis
Solution Approach 1:
The patent combines multiple peptide agents with different biological activities into a single cosmetic formulation. The formulation includes at least two peptides: one that stimulates stem cell proliferation and another that modulates inflammation, creating a synergistic effect that overcomes the limitations of single-target approaches while addressing multiple aspects of skin regeneration simultaneously
Solution Approach 2:
The cosmetic formulation is designed to perform multiple functions through its peptide components: stimulating stem cell proliferation, modulating inflammatory responses, promoting tissue regeneration, and maintaining skin homeostasis. This multi-functional approach allows a single formulation to address various aspects of skin damage repair without requiring multiple separate products
2Duration of action of stationary object
If conventional interventions provide short-term modulation, then the formulation is simple, but persistent reliance is required and regulatory deadlocks cannot be overcome
Solution Approach 1:
The formulation includes peptides that are designed to act in advance on multiple regulatory pathways simultaneously. By pre-combining peptides that target stem cell proliferation, inflammation modulation, and tissue regeneration in a single formulation, the product establishes a coordinated regenerative response from the outset, preventing regulatory deadlocks before they can develop rather than requiring repeated short-term interventions
Solution Approach 2:
The synergistic combination of multiple peptides creates a continuous and coordinated regenerative action that sustains skin repair processes over time. The formulation maintains balanced activation of multiple biological pathways simultaneously, ensuring persistent therapeutic effect without requiring frequent reapplication or creating dependency on repeated treatments
3Reliability
If multiple peptide agents are combined for synergistic action, then the regenerative efficacy is improved, but the formulation complexity increases
Solution Approach 1:
The formulation is segmented into distinct peptide components, each with a specific biological function: one peptide targets stem cell proliferation through Wnt pathway activation, another modulates inflammation via NF-κB pathway interaction, and additional peptides address specific aspects of tissue regeneration. This functional segmentation allows each component to be optimized for its specific role while maintaining overall formulation simplicity through modular design
Data Source
AI summary
The invention relates to novel nature-derived and synthetic active peptide- or peptide-derived agents designed for the cosmetic treatment of the human skin, as well to cosmetic formulations and compositions containing them. The active agents are effective in restoring, promoting and maintaining a healthy skin. In particular, the invention discloses combinations or sets of said skin effective agents including stem-cell factors that modulate the skin micromilieu and modulate skin stem cell behaviour, thereby effectively healing, regenerating and improving the state of aged or damaged skin.