Peptone-Based Pharmaceutical Foam for Stable Medical Applications
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Solution Overview
Problem
Existing pharmaceutical foams prepared from full-length proteins lack sufficient strength and durability, which is crucial for medical and surgical applications, as they often require higher molecular mass for stability but result in foams that are not strong enough for extended use or repeated applications.
Innovation Solution
The development of a pharmaceutical foam composition using peptones, which are short peptide lengths obtained by enzymatic hydrolysis of full-length proteins, creating a stable foam with superior compression strength and durability, free from the full-length protein, and optionally including fibrin, fibrinogen, and thrombin for enhanced properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If full-length proteins are used as surfactants to form foam, then the foam can be formed with higher molecular mass providing stability, but the compression strength and durability of the foam are insufficient for extended medical use
Solution Approach 1:
The full-length protein is segmented into smaller peptide fragments through enzymatic hydrolysis. These peptide fragments (e.g., 90 or fewer amino acids) maintain the ability to form stable micelles and foam structures while providing superior compression strength and durability compared to full-length proteins.
Solution Approach 2:
The molecular mass parameter of the surfactant is changed from full-length protein (high molecular mass) to peptone/peptide fragments (lower molecular mass). This parameter change resolves the contradiction by showing that lower molecular mass peptides can achieve both foam stability and enhanced compression strength.
2Stability of the object's composition
If full-length proteins are used to prepare foam, then the foam structure can be maintained, but the immunogenicity remains high which limits medical application safety
Solution Approach 1:
Segmenting the full-length protein into smaller peptide fragments through enzymatic hydrolysis reduces the immunogenicity while preserving the foam-forming capability. The peptide fragments maintain structural integrity for foam formation but present fewer immunogenic epitopes.
3Duration of action of stationary object
If full-length proteins are used as foam basis, then the foam can be formed, but the degradation rate in vivo is slow which delays wound healing
Solution Approach 1:
Changing the molecular size parameter from full-length protein to peptone/peptide fragments creates a foam that degrades faster in vivo. The smaller peptide fragments are more readily broken down by proteolytic enzymes in the body, accelerating degradation while maintaining sufficient durability for the intended application duration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peptone-based foam exhibits higher tensile strength, reduced immunogenicity, increased adhesiveness, and faster in-vivo degradation, making it more suitable for medical applications such as wound healing, hemostasis, and anti-adhesion, while maintaining stability and structural integrity over time.
Implementation Method 1
peptones prepared by enzymatic hydrolysis of a full-length protein
Implementation Method 2
an amphiphilic agent is required i.e. a molecule which has both a hydrophilic group and a hydrophilic group, allowing the strands of denatured proteins to form micelles, within which gas, such as air, is trapped
Implementation Method 3
the addition of a surfactant is generally required in order to reduce the surface tension of the liquid, enabling mixing of the gas with the liquid to form a stable foam
Data Source
AI summary
Provided are pharmaceutical foam compositions comprising a peptone, a peptide hydrolysate or an enzymatically-hydrolyzed protein prepared by enzymatic hydrolysis of a full-length protein; methods of preparation and uses thereof.