Peracetic Acid Disinfectant Stabilization with Chelating Agents
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Solution Overview
Problem
The shelf life of peroxidic disinfectant systems used for disinfecting medical instruments is limited, necessitating the development of a composition that stabilizes peracetic acid for extended periods.
Innovation Solution
A disinfectant composition comprising a peracetic acid-generating component with acetic acid and hydrogen peroxide, combined with a stabilizer component including an alkaline agent and a chelating agent such as N,N-bis(carboxymethyl)-L-glutamic acid, methylglycine diacetic acid, or nitrilotriacetic acid, which stabilizes peracetic acid in aqueous solutions for up to 14 days.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional peroxidic disinfectant systems are used, then disinfection capability is achieved, but shelf life is limited
Solution Approach 1:
The patent introduces a chelating agent as an intermediary substance that mediates between the peracetic acid and metal ions in the solution. The chelating agent binds to metal ions, preventing them from catalyzing the decomposition of peracetic acid, thereby extending shelf life while maintaining disinfection capability
Solution Approach 2:
The patent modifies the chemical composition parameters of the disinfectant system by adding specific chelating agents (N,N-bis(carboxymethyl)-L-glutamic acid, methylglycine diacetic acid, or nitrilotriacetic acid) at optimized concentrations. This parameter change stabilizes the peracetic acid solution, extending shelf life from conventional limits to over 7 days while preserving disinfection effectiveness
2Stability of the object's composition
If peracetic acid concentration is maintained for extended shelf life, then stability is improved, but disinfection effectiveness may be compromised
Solution Approach 1:
The patent optimizes multiple parameters simultaneously: chelating agent concentration (0.01-5% w/v), pH level (3-7), and peracetic acid concentration (100-5000 ppm). This multi-parameter optimization achieves both extended stability and maintained disinfection effectiveness, as the chelating agent protects peracetic acid from decomposition without interfering with its biocidal activity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively prolongs the shelf life of the disinfectant solution, maintaining peracetic acid levels above 1000 ppm for over 7 days and up to 14 days, ensuring effective disinfection of medical instruments without significant degradation.
Implementation Method 1
a stabilizer component comprising an alkaline agent and a chelating agent, wherein the chelating agent is selected from the group consisting of N,N-bis(carboxymethyl)L-glutamic acid, methylglycine diacetic acid, nitrilotriacetic acid, and alkali metal salts thereof
Implementation Method 2
a peracetic acid-generating component comprising acetic acid, hydrogen peroxide and an organic phosphonic acid
Data Source
AI summary
The invention relates to a disinfectant composition comprising:(A) a peracetic acid-generating component comprising acetic acid, hydrogen peroxide and an organic phosphonic acid; and(B) a stabilizer component comprising an alkaline agent and a chelating agent,wherein the chelating agent is selected from the group consisting of N,N-bis(carboxymethyl)L-glutamic acid, methylglycine diacetic acid, nitrilotriacetic acid, and alkali metal salts thereof, and a mixture of two or more thereof and to the aqueous disinfectant solution obtainable by mixing and diluting components (A) and (B) in water.The invention further relates to a method of disinfecting surface and instruments, particularly flexible endoscopes, using said aqueous disinfectant solution.