Percutaneous Spray System Using Oxygen Propellant
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Solution Overview
Problem
Current methods for transdermal administration of pharmaceutical and cosmetic active ingredients face challenges in overcoming the skin's barrier function, particularly in delivering oxygen and larger molecules effectively, leading to low absorption rates and systemic side effects.
Innovation Solution
A system utilizing a Laval nozzle with a propellant gas consisting of at least 25% oxygen, which atomizes and accelerates the active ingredient composition to high exit velocities (>100 m/s), allowing for deeper skin penetration and simultaneous oxygen delivery, thereby overcoming the skin's barrier and enhancing the therapeutic effect.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If conventional spray systems are used to apply preparations to the skin, then the application process is simple and widely used, but the skin barrier function prevents effective transdermal transport of active ingredients
Solution Approach 1:
The patent employs a pneumatic spray system using compressed gas (at least 25% oxygen by volume) to atomize and deliver the active ingredient composition. The gas pressure (1-7 bar) enables the formulation to penetrate the skin barrier more effectively than conventional application methods, resolving the contradiction between ease of application and transdermal transport effectiveness.
Solution Approach 2:
The patent changes the physical parameters of the spray delivery system by using a Laval nozzle to accelerate the propellant gas to high exit velocities (>100 m/s). This parameter change enhances the penetration capability through the skin barrier while maintaining the simplicity of the spray application process.
2Reliability
If electroporation or sonophoresis methods are used to overcome the skin barrier, then active ingredient penetration is improved, but oxygen supply to the skin is not achieved
Solution Approach 1:
The patent creates a multi-functional spray system where the propellant gas serves dual purposes: (1) as a delivery medium for active ingredients through atomization and penetration enhancement, and (2) as an oxygen source that is simultaneously delivered to the skin. This resolves the contradiction by making the system versatile enough to provide both active ingredient penetration and oxygen supply through a single application process.
Solution Approach 2:
The patent merges the functions of active ingredient delivery and oxygen therapy into a single integrated spray system. The formulation contains both the active ingredient and dissolved oxygen, and the Laval nozzle delivers both components simultaneously to the skin, eliminating the need for separate treatment procedures.
3Reliability
If jet injections are used to deliver active ingredients, then penetration depth is increased, but skin injury occurs
Solution Approach 1:
The patent uses a pneumatic spray system with controlled gas pressure (1-7 bar) and a Laval nozzle to deliver the formulation. This approach achieves significant penetration depth (>100 m/s exit velocity) while avoiding the skin injury associated with jet injections, as the atomized spray delivers the active ingredients through controlled deposition rather than high-velocity impact.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables the effective transdermal transport of active ingredients and oxygen, achieving significant penetration depths and synergistic therapeutic effects, with improved analgesia, anti-inflammatory, and cosmetic outcomes without causing skin injury.
Implementation Method 1
the propellant gas atomizes the sprayable composition and drives it out of the spray device
Implementation Method 2
A system utilizing a Laval nozzle with a propellant gas consisting of at least 25% oxygen, which atomizes and accelerates the active ingredient composition to high exit velocities (>100 m/s)
Implementation Method 3
achieving significant penetration depths and synergistic therapeutic effects, with improved analgesia, anti-inflammatory, and cosmetic outcomes
Data Source
Figure 1
AI summary
The invention relates to an application system for trans-epidermal surface administration of drugs, comprising a container (1) for receiving a sprayable composition containing an active compound, a propellant gas source (3) for a gas under pressure, of which at least 25% by volume consists of oxygen, and a spraying device (2), wherein the container (1), propellant gas source (3) and spraying device (2) are connected fluidically to one another in such a way that when the spraying device (2) is activated, the propellant gas atomizes the sprayable composition and drives the latter out of the spraying device (2), wherein the composition is driven out of the spraying device (2) in a conical spray jet having an exit velocity = 100 m/s. With the aid of the application system according to the invention, it is possible to administer active compounds effectively via the skin without any injury to the skin. On account of the high exit velocity, the introduction rate is particularly effective even when relatively large molecules are applied.